DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vis and irx2

DIOPT Version :9

Sequence 1:	NP_788337.1	Gene:	vis / 36372	FlyBaseID:	FBgn0033748	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001008113.1	Gene:	irx2 / 493475	XenbaseID:	XB-GENE-480618	Length:	456	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	86/406 - (21%)
Similarity:	133/406 - (32%)	Gaps:	121/406 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 RGNLPKSSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGN 159
            |.|..:.:...||.||.|||.|.||:..||..|:....:|:.||..||.|||||     :::|..
Frog   114 RKNATRDATATLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKENK 173

  Fly   160 DPLHFTISRRGKKVVGATEEVDGAGEIHEGIANVLTNFEQYVQGPNGQMVK----------MEPE 214
                .|.:.|.|    :.:|.|..|:                    |:.||          .|..
Frog   174 ----MTWAPRNK----SEDEDDDEGD--------------------GERVKEEQSEKAQDCNETS 210

  Fly   215 YEDSVIYSWQQAIANNPMGFQSLHSSLQATMIDKIKNYQMRKAAAIGGSAVGSGG---------- 269
            .||..|               |||       :|.:.::..        ||...|.
Frog   211 AEDEGI---------------SLH-------VDSLTDHSC--------SADSDGEKLPCRATDHL 245

  Fly   270 -AGGSSSNS--------------------SPATSILPYSLFGQLPPEFDDEEKPRPPKRVRTRTV 313
             ..||.|..                    .||||   ..|.|...|..:.::...|....:|...
Frog   246 CESGSESKEKYDDDEDEEEGDEEDRVLPVKPATS---SPLTGVEAPILNHQQDGSPRNSNKTSLD 307

  Fly   314 AAKSPRENAKQAKQKTGNKQETMYC-YKDSYGGIVVSPRSEGEESAQGYES----------CGPN 367
            ...||......:|.|..:..|.... :|.|..|.|:|..:........|.|          ..|.
Frog   308 NGMSPSSQTPASKPKLWSLAEIATSDHKHSNLGSVLSSATSSAAHNPSYPSSSLLGRHIYYTSPF 372

  Fly   368 SEEEVRFETSHDWQSVIKTVFGTEEVSTSAGNNPGTSGSKASVQNTAIWNRNQTAKRDVNQQLTD 432
            ......:...:..||.....:.:..|:.:.|.|.....:.:..::|:...|..:.:.|.:.:.|:
Frog   373 YSNYTNYGNFNALQSQGILRYSSAAVTANEGLNQTVLSTSSMHKHTSDSVRTASNQLDQHYRPTN 437

  Fly   433 FESELNIIQASEIQTI 448
            |||:.:   .||:.|:
Frog   438 FESKKD---PSEVCTV 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	109..148	CDD:283551	19/38 (50%)
irx2	NP_001008113.1	COG5576	<110..212	CDD:227863	36/130 (28%)
		Homeobox_KN	128..167	CDD:368670	19/38 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..214		11/69 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..320		14/76 (18%)
		IRO	317..333	CDD:214716	3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..456		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000