DRSC/TRiP Functional Genomics Resources

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Protein Alignment vis and MEIS2

DIOPT Version :9

Sequence 1:NP_788337.1 Gene:vis / 36372 FlyBaseID:FBgn0033748 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_733775.1 Gene:MEIS2 / 4212 HGNCID:7001 Length:477 Species:Homo sapiens


Alignment Length:262 Identity:74/262 - (28%)
Similarity:114/262 - (43%) Gaps:46/262 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VNMVLDRHVRQNIKDLMHEAHVHASLLN----NEGRDRFHSDSSLDQDS--------LHAVVGND 61
            :::|:|.....:..|  || .:..|..|    |....|.|.|::....:        .||....|
Human   185 IDLVIDERDGSSKSD--HE-ELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGD 246

  Fly    62 LSTEQGANQVQNYHDMMVDSEHHVDINGSLRKRRGNLPKSSVKILKRWLYEHRYNAYPSDAEKFT 126
            .|:|||.....:........:...|.:...:|:||..||.:..|::.||::|..:.|||:.:|..
Human   247 NSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQ 311

  Fly   127 LSQEANLTVLQVCNWFINARRRILPEMIRREGN-----DPLHFTISRRGKKVVGATEEVDGA--- 183
            |:|:..||:|||.||||||||||:..||.:...     ||   ::|:      ||....:|.   
Human   312 LAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDP---SVSQ------GAAYSPEGQPMG 367

  Fly   184 -----GEIHEGI--ANVLTNFEQYVQ--GPNGQMVKMEPEYEDSVIYSWQQAIANNPMGFQSLHS 239
                 |:.|.||  |.:.:....||.  ||.| |...:|.|....:......:.:.|    .:||
Human   368 SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMG-MSMAQPSYTPPQMTPHPTQLRHGP----PMHS 427

  Fly   240 SL 241
            .|
Human   428 YL 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
visNP_788337.1 Homeobox_KN 109..148 CDD:283551 21/38 (55%)
MEIS2NP_733775.1 Required for interaction with PBX1. /evidence=ECO:0000250 71..191 1/5 (20%)
Meis_PKNOX_N 110..194 CDD:406806 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..283 20/92 (22%)
Homeobox_KN 294..333 CDD:399131 21/38 (55%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16 299..333 18/33 (55%)
PAT1 <335..>463 CDD:401645 25/109 (23%)
Transcriptional activation domain 340..477 23/104 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152674
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0773
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2315
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.770

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