Protein Alignment vis and MKX

DIOPT Version :10

• Sequence 1: NP_788337.1
• Gene: vis / 36372
• FlyBaseID: FBgn0033748
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_775847.2
• Gene: MKX / 283078
• HGNCID: 23729
• Length: 352
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 91/390 - (23%)
• Similarity: 153/390 - (39%)
• Gaps: 102/390 - (26%)

  Fly    54 LHAVVGNDLS-----TEQGANQVQ---NYHDMMVDSEH---HVDI--------NGSLRKRRGNLP 99
            ::.:|.|.||     .:.||::.:   ..:..::||.|   .|.|        |..||.||....
Human     1 MNTIVFNKLSGAVLFEDGGASERERGGRPYSGVLDSPHARPEVGIPDGPPLKDNLGLRHRRTGAR 65

  Fly   100 KSSVKI-------------LKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILP 151
            ::..|:             ||:|||:||.|.||:..||..|:..:.:|::||.|||.|||||:..
Human    66 QNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKN 130

  Fly   152 EMIRREGNDPLHFTISRRGKKVVGATEEV-----DGAGEIHEGIANVLTNFEQYVQGPNGQMVKM 211
            .:  |:.:......|....|.|.|..|.:     |...|..|.......|...|....:..::|.
Human   131 TV--RQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSEDGENPPRTHMNEGGYNTPVHHPVIKS 193

  Fly   212 E---------PEYEDSVIYSWQQAIANNPMGFQSLHSSLQATMIDKIKNYQMRKAAAIGGSAVGS 267
            |         ||...|..|     :|  |..::|       :::::..|..:|...|...:.:|.
Human   194 ENSVIKAGVRPESRASEDY-----VA--PPKYKS-------SLLNRYLNDSLRHVMATNTTMMGK 244

  Fly   268 ----GGAGGSSSNSSPATSILPYSLFGQLPPEFDDEEKPRPPKRVRT------RTVAAKSPRENA 322
                ..:|..|||                  ||  ||:...|....|      ||...::.....
Human   245 TRQRNHSGSFSSN------------------EF--EEELVSPSSSETEGNFVYRTDTLENGSNKG 289

  Fly   323 KQAKQKTGNKQETMYCYKDSYGGIVVSPRSEGEESAQGYESCGPNSEEEVRFETSHDWQSVIKTV 387
            :.|..:.|..::..| :|:....:.::..::|::..||..||       :..::||  .:.:|||
Human   290 ESAANRKGPSKDDTY-WKEINAAMALTNLAQGKDKLQGTTSC-------IIQKSSH--IAEVKTV 344

  Fly   388  387
            Human   345  344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	110..148	CDD:428673	19/37 (51%)
MKX	NP_775847.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..54		7/34 (21%)
		Homeobox_KN	89..127	CDD:428673	19/37 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..189		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..301		14/75 (19%)