DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and Sctr

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_038947043.1	Gene:	Sctr / 81779	RGDID:	621342	Length:	464	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	136/456 - (29%)
Similarity:	217/456 - (47%)	Gaps:	73/456 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LQNRTLQCQQQQQREEE--------QASLEALASGGKRILQ-CPSSFDSVLCWPRTNAGSLAVLP 106
            |:.|. .|.||..:|::        .||:.:..:....:.| |...:|::.|||.:.......:.
  Rat    40 LEERA-HCLQQLSKEKKGALGPETASASVFSPFASSHAVYQGCEGLWDNMSCWPSSAPARTVEVQ 103

  Fly   107 CFEEFKGVHYDTTDNATRFCFPNGTWDHYSD-YDRCHQNSGSIPVVPDFSPNVELP--------- 161
            | .:|..:    ..|.....|.|.|.|.:|: :.|           ||.:..|.:.
  Rat   104 C-PKFLLM----LSNKNGSLFRNCTQDGWSETFPR-----------PDLACGVNINNSFNERRHA 152

  Fly   162 -----AIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWIL---TLFL- 217
                 .::|..||..|.|.|:|||.|..||:.|.|.||.||.:||:::|..||...:   .||.
  Rat   153 YLLKLKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSS 217

  Fly   218 -QVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPA 281
             .|...::.:.||..::|.|||..:.|:.|:.||||||:||:..:|.|:......:.|:|||.||
  Rat   218 DDVTYCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKYLQAFVLLGWGSPA 282

  Fly   282 VCILVWSIAKAFAPHLENEHFNGLEIDCA-WMRESHIDWIFKVPASLALLVNLVFLIRIMWVLIT 345
            :.:.:|:|.:.|   |||.....:..:.: |       |:.:.|..|::|:|.:|.|.|:.:|:.
  Rat   283 IFVALWAITRHF---LENTGCWDINANASVW-------WVIRGPVILSILINFIFFINILRILMR 337

  Fly   346 KLRSAHT--LETRQYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVA 408
            |||:..|  .||..|.:.:|:.|:|||||||.|::....||..:...||  ....|.|.||..||
  Rat   338 KLRTQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSPEDAMEVQLF--FELALGSFQGLVVA 400

  Fly   409 LFYCFLNSEVRQTLRHGFTRWR----ESRNIHRNSSIKNRSTEECVICLRPSPHTRLGSLQRYHS 469
            :.|||||.||:..::..:.:|.    ..|.:..|:|..|.:.       .|: |:...|.::..|
  Rat   401 VLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVAFNNSFSNATN-------GPT-HSTKASTEQSRS 457

  Fly   470 I 470
            |
  Rat   458 I 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	15/63 (24%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	91/269 (34%)
Sctr	XP_038947043.1	HormR	80..147	CDD:214468	17/82 (21%)
		7tmB1_secretin	154..420	CDD:320403	100/277 (36%)
		TM helix 1	157..181	CDD:320403	10/23 (43%)
		TM helix 2	190..211	CDD:320403	8/20 (40%)
		TM helix 3	231..253	CDD:320403	8/21 (38%)
		TM helix 4	272..288	CDD:320403	6/15 (40%)
		TM helix 5	306..329	CDD:320403	7/29 (24%)
		TM helix 6	356..378	CDD:320403	10/21 (48%)
		TM helix 7	382..407	CDD:320403	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810