Protein Alignment Dh44-R2 and ghrhrb

DIOPT Version :10

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: XP_001331921.5
• Gene: ghrhrb / 792410
• ZFINID: ZDB-GENE-110127-2
• Length: 453
• Species: Danio rerio
• Alignment Length: 459
• Identity: 127/459 - (27%)
• Similarity: 209/459 - (45%)
• Gaps: 72/459 - (15%)

  Fly    29 SVDMLQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSVLC 93
            :|:.:..|.||:.|...:..        ||...|::|.:..:         .:..||:.:|...|
Zfish    28 AVETIHPACALVAAHMKAQE--------QCNATQRQESQNRN---------NVTGCPTEWDEFWC 75

  Fly    94 WPRTNAGSLAVLPCFEEFK-GVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSGSIPVVPDFSPN 157
            |.....|.:..:.|.|..: .|::.       |.|.|.|.|.:::....::|  :..:|.|....
Zfish    76 WSGAEVGQVVNISCSEVSQLFVNHG-------FIFRNCTKDGWTEVYPSYEN--ACEIVEDVESE 131

  Fly   158 VELPAI-----IYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFL 217
            .|....     :|..||..|..:|:.|:.:|..|:...|.||.||.|||.::|..|    ..:|:
Zfish   132 TETTYYATFRQVYTAGYATSLISLITAIFVFTVFRKFHCTRNYIHINLFASFILRA----SAIFI 192

  Fly   218 Q---VITTES------SQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYA 273
            :   :...|:      |...|...|..||:..|.|:||:.|||:||.||:..||.|....|..|.
Zfish   193 KDAVLFADENLDHCFMSTTSCKAAVAFFQFSILANYFWLLVEGMYLQTLLALTFVSQKKYFWWYI 257

  Fly   274 LIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLIR 338
            |||||.|.:.:.:|.:|:.|..:  |..::..::...|       ||.|.|.:::||:|.:..|.
Zfish   258 LIGWGLPTLILTIWVLARNFFDN--NGCWDDTDVAYFW-------WIIKGPITVSLLINFLIFIN 313

  Fly   339 IMWVLITKLRSAHT--LETRQYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLI- 400
            ::.:|:.||:|...  .:|..:.:.:|:.|.||||||:.|::....||     |..|..|.||.
Zfish   314 VIRILVQKLKSPGMGGGDTNHFMRLAKSTLFLIPLFGMHYMVFAFLPE-----NTGENARHFLEL 373

  Fly   401 ---STQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNIHRNSSIKNRSTEECVICLRPSPHTRLG 462
               ..|||.|||.|||||.||:..|:....:|:....:..:...:...||...:       |::.
Zfish   374 GLGPFQGFVVALLYCFLNGEVQAELKKRLWKWQTQSYLRYSKRRRTLFTESSTV-------TQIS 431

  Fly   463 SLQR 466
            .|::
Zfish   432 VLEK 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:397086	14/62 (23%)
		7tmB1_DH_R	158..428	CDD:320391	96/289 (33%)
		TM helix 1	160..185	CDD:320391	7/29 (24%)
		TM helix 2	194..216	CDD:320391	8/21 (38%)
		TM helix 3	230..257	CDD:320391	12/26 (46%)
		TM helix 4	269..289	CDD:320391	9/19 (47%)
		TM helix 5	314..343	CDD:320391	8/28 (29%)
		TM helix 6	357..384	CDD:320391	9/26 (35%)
		TM helix 7	390..415	CDD:320391	14/28 (50%)
ghrhrb	XP_001331921.5	HRM	65..123	CDD:397086	15/66 (23%)
		7tmB1_GHRHR2	137..404	CDD:320399	95/284 (33%)
		TM helix 1	139..164	CDD:320399	7/24 (29%)
		TM helix 2	173..195	CDD:320399	9/25 (36%)
		TM helix 3	214..241	CDD:320399	12/26 (46%)
		TM helix 4	253..273	CDD:320399	9/19 (47%)
		TM helix 5	288..318	CDD:320399	9/36 (25%)
		TM helix 6	334..361	CDD:320399	9/26 (35%)
		TM helix 7	366..391	CDD:320399	12/24 (50%)