DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and ghrhrb

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_021333028.1	Gene:	ghrhrb / 792410	ZFINID:	ZDB-GENE-110127-2	Length:	529	Species:	Danio rerio

Alignment Length:	427	Identity:	123/427 - (28%)
Similarity:	201/427 - (47%)	Gaps:	57/427 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 QQQREEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFK-GVHYDTTDNATR 124
            |::|.:.:||  :.....|.:..||:.:|...||.....|.:..:.|.|..: .|::.
Zfish   121 QKRRRKRKAS--SARHHCKALRGCPTEWDEFWCWSGAEVGQVVNISCSEVSQLFVNHG------- 176

  Fly   125 FCFPNGTWDHYSDYDRCHQNSGSIPVVPDFSPNVELPAI-----IYAGGYFLSFATLVVALIIFL 184
            |.|.|.|.|.:::....::|  :..:|.|.....|....     :|..||..|..:|:.|:.:|.
Zfish   177 FIFRNCTKDGWTEVYPSYEN--ACEIVEDVESETETTYYATFRQVYTAGYATSLISLITAIFVFT 239

  Fly   185 SFKDLRCLRNTIHANLFLTYITSALLWILTLFLQ---VITTES------SQAGCITLVIMFQYFY 240
            .|:...|.||.||.|||.::|..|    ..:|::   :...|:      |...|...|..||:..
Zfish   240 VFRKFHCTRNYIHINLFASFILRA----SAIFIKDAVLFADENLDHCFMSTTSCKAAVAFFQFSI 300

  Fly   241 LTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGL 305
            |.|:||:.|||:||.||:..||.|....|..|.|||||.|.:.:.:|.:|:.|..:  |..::..
Zfish   301 LANYFWLLVEGMYLQTLLALTFVSQKKYFWWYILIGWGLPTLILTIWVLARNFFDN--NGCWDDT 363

  Fly   306 EIDCAWMRESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHT--LETRQYYKASKALLVL 368
            ::...|       ||.|.|.:::||:|.:..|.::.:|:.||:|...  .:|..:.:.:|:.|.|
Zfish   364 DVAYFW-------WIIKGPITVSLLINFLIFINVIRILVQKLKSPGMGGGDTNHFMRLAKSTLFL 421

  Fly   369 IPLFGITYLLVLTGPEQGISRNLFEAIRAFLI----STQGFFVALFYCFLNSEVRQTLRHGFTRW 429
            |||||:.|::....||     |..|..|.||.    ..|||.|||.|||||.||:..|:....:|
Zfish   422 IPLFGMHYMVFAFLPE-----NTGENARHFLELGLGPFQGFVVALLYCFLNGEVQAELKKRLWKW 481

  Fly   430 RESRNIHRNSSIKNRSTEECVICLRPSPHTRLGSLQR 466
            :....:..:...:...||...:       |::..|::
Zfish   482 QTQSYLRYSKRRRTLFTESSTV-------TQISVLEK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	14/62 (23%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	85/267 (32%)
ghrhrb	XP_021333028.1	HRM	141..199	CDD:308439	15/66 (23%)
		7tmB1_GHRHR2	213..480	CDD:320399	95/284 (33%)
		TM helix 1	215..240	CDD:320399	7/24 (29%)
		TM helix 2	249..271	CDD:320399	9/25 (36%)
		TM helix 3	290..317	CDD:320399	12/26 (46%)
		TM helix 4	329..349	CDD:320399	9/19 (47%)
		TM helix 5	364..394	CDD:320399	9/36 (25%)
		TM helix 6	410..437	CDD:320399	9/26 (35%)
		TM helix 7	442..467	CDD:320399	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910