DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and adcyap1r1

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_031759329.1	Gene:	adcyap1r1 / 780260	XenbaseID:	XB-GENE-5805848	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	493	Identity:	131/493 - (26%)
Similarity:	211/493 - (42%)	Gaps:	128/493 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 REEEQASLEAL----------ASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGV---- 114
            ::||:|.||.:          ...|     ||..:|::.||.....|.:..:.|...|..:
Frog    28 KKEEEACLEKIQRYEIEMWNDTQPG-----CPGMWDNITCWMPAEVGKVVSIRCPALFSMLGSED 87

  Fly   115 HYDTTDNA-----------------TRFCFPNGTWDHYSDY-DRCHQNSGSIPVVPDFSPNVELP 161
            ..|..|.:                 ||.|..||..||:..| :.|           ||..|...|
Frog    88 EMDFVDRSLGWAPENLEEQQSAGIITRNCTENGWTDHFPHYSEAC-----------DFDINETGP 141

  Fly   162 ---------AIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFL 217
                     ..:|..||..|...|..|::|...|:.|.|.||.||.|||:::|..|    :::|:
Frog   142 DQDTYYLSVKALYTVGYSTSLVALTTAMVILCRFRKLHCTRNFIHMNLFVSFILRA----ISVFI 202

  Fly   218 --QVITTES-------SQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYA 273
              :|:..|.       |...|..:::.|.|..::|:||:|:|||||:||:|:||..:...|..|.
Frog   203 KDEVLYAEQDSNHCHLSTVECKVVMVFFHYCVMSNYFWLFIEGLYLFTLLVETFFPERRYFYWYT 267

  Fly   274 LIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESH-IDWIFKVPASLALLVNLVFLI 337
            :||||.|.:|:.:|::.:.        ||:  ::.|..|.::. :.|:.|.|...::::|.|..:
Frog   268 IIGWGTPLICVTIWAVLRL--------HFD--DVGCWDMNDNFALWWVIKGPVIGSIMINFVLFV 322

  Fly   338 RIMWVLITKLRS--------------------------AHTLETRQY----YKASKALLVLIPLF 372
            .|:.:|:.||:|                          .|:.:..:.    .:.:::.|:|||||
Frog   323 GIIIILVQKLQSPDIGGNESSIYFSCFQKCFCKTKRANEHSFKMSELSIITLRLARSTLLLIPLF 387

  Fly   373 GITYLLVLTGPEQGISRN--LFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNI 435
            ||.|.:....||....|.  :||   ..|.|.|||.||:.|||||.|.   |..|..|.:|
Frog   388 GIHYTVFAFSPENVSKRERLVFE---LGLGSFQGFVVAILYCFLNGEF---LPKGAIRNKE---- 442

  Fly   436 HRNSSIKNRSTEECVICLRPSPHTRLGSLQRYHSIDIT 473
                .::...::..:.|...:|.:..|. ||....|.|
Frog   443 ----EMEELESQPVLCCGFQTPPSVSGE-QRSERRDTT 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	19/83 (23%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	84/298 (28%)
adcyap1r1	XP_031759329.1	HRM	50..135	CDD:397086	21/100 (21%)
		7tm_GPCRs	147..431	CDD:421689	90/300 (30%)
		TM helix 1	149..174	CDD:410628	7/24 (29%)
		TM helix 2	183..205	CDD:410628	9/25 (36%)
		TM helix 3	224..251	CDD:410628	11/26 (42%)
		TM helix 4	263..283	CDD:410628	9/19 (47%)
		TM helix 5	299..328	CDD:410628	6/28 (21%)
		TM helix 6	344..399	CDD:410628	10/54 (19%)
		TM helix 7	404..429	CDD:410628	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000