Protein Alignment Dh44-R2 and adcyap1r1

DIOPT Version :10

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: XP_031759329.1
• Gene: adcyap1r1 / 780260
• XenbaseID: XB-GENE-5805848
• Length: 503
• Species: Xenopus tropicalis
• Alignment Length: 493
• Identity: 131/493 - (26%)
• Similarity: 211/493 - (42%)
• Gaps: 128/493 - (25%)

  Fly    64 REEEQASLEAL----------ASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGV---- 114
            ::||:|.||.:          ...|     ||..:|::.||.....|.:..:.|...|..:
 Frog    28 KKEEEACLEKIQRYEIEMWNDTQPG-----CPGMWDNITCWMPAEVGKVVSIRCPALFSMLGSED 87

  Fly   115 HYDTTDNA-----------------TRFCFPNGTWDHYSDY-DRCHQNSGSIPVVPDFSPNVELP 161
            ..|..|.:                 ||.|..||..||:..| :.|           ||..|...|
 Frog    88 EMDFVDRSLGWAPENLEEQQSAGIITRNCTENGWTDHFPHYSEAC-----------DFDINETGP 141

  Fly   162 ---------AIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFL 217
                     ..:|..||..|...|..|::|...|:.|.|.||.||.|||:::|..|    :::|:
 Frog   142 DQDTYYLSVKALYTVGYSTSLVALTTAMVILCRFRKLHCTRNFIHMNLFVSFILRA----ISVFI 202

  Fly   218 --QVITTES-------SQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYA 273
              :|:..|.       |...|..:::.|.|..::|:||:|:|||||:||:|:||..:...|..|.
 Frog   203 KDEVLYAEQDSNHCHLSTVECKVVMVFFHYCVMSNYFWLFIEGLYLFTLLVETFFPERRYFYWYT 267

  Fly   274 LIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESH-IDWIFKVPASLALLVNLVFLI 337
            :||||.|.:|:.:|::.:.        ||:  ::.|..|.::. :.|:.|.|...::::|.|..:
 Frog   268 IIGWGTPLICVTIWAVLRL--------HFD--DVGCWDMNDNFALWWVIKGPVIGSIMINFVLFV 322

  Fly   338 RIMWVLITKLRS--------------------------AHTLETRQY----YKASKALLVLIPLF 372
            .|:.:|:.||:|                          .|:.:..:.    .:.:::.|:|||||
 Frog   323 GIIIILVQKLQSPDIGGNESSIYFSCFQKCFCKTKRANEHSFKMSELSIITLRLARSTLLLIPLF 387

  Fly   373 GITYLLVLTGPEQGISRN--LFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNI 435
            ||.|.:....||....|.  :||   ..|.|.|||.||:.|||||.|.   |..|..|.:|
 Frog   388 GIHYTVFAFSPENVSKRERLVFE---LGLGSFQGFVVAILYCFLNGEF---LPKGAIRNKE---- 442

  Fly   436 HRNSSIKNRSTEECVICLRPSPHTRLGSLQRYHSIDIT 473
                .::...::..:.|...:|.:..|. ||....|.|
 Frog   443 ----EMEELESQPVLCCGFQTPPSVSGE-QRSERRDTT 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:397086	19/83 (23%)
		7tmB1_DH_R	158..428	CDD:320391	94/320 (29%)
		TM helix 1	160..185	CDD:320391	8/33 (24%)
		TM helix 2	194..216	CDD:320391	8/21 (38%)
		TM helix 3	230..257	CDD:320391	11/26 (42%)
		TM helix 4	269..289	CDD:320391	9/19 (47%)
		TM helix 5	314..343	CDD:320391	6/29 (21%)
		TM helix 6	357..384	CDD:320391	9/30 (30%)
		TM helix 7	390..415	CDD:320391	12/26 (46%)
adcyap1r1	XP_031759329.1	HRM	50..135	CDD:397086	21/100 (21%)
		7tm_GPCRs	147..431	CDD:475119	90/300 (30%)
		TM helix 1	150..174	CDD:410628	7/23 (30%)
		TM helix 2	183..204	CDD:410628	9/24 (38%)
		TM helix 3	224..246	CDD:410628	7/21 (33%)
		TM helix 4	265..281	CDD:410628	7/15 (47%)
		TM helix 5	299..322	CDD:410628	5/22 (23%)
		TM helix 6	377..399	CDD:410628	9/21 (43%)
		TM helix 7	404..429	CDD:410628	13/27 (48%)