DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Crhr1

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_112261.1	Gene:	Crhr1 / 58959	RGDID:	61276	Length:	415	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	169/446 - (37%)
Similarity:	238/446 - (53%)	Gaps:	53/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSV-LCWPR 96
            |.:|..|:|....|:..|.|    :|        |..||.:..||    |||.:|.|.: .||||
  Rat     9 LVKALLLLGLNPVSTSLQDQ----RC--------ENLSLTSNVSG----LQCNASVDLIGTCWPR 57

  Fly    97 TNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQ--NSGSIPVVPDFSPNVE 159
            :.||.|.|.||...|.||.|:||:|..|.|..||:|....:|..|.:  |......|     :..
  Rat    58 SPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKV-----HYH 117

  Fly   160 LPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLW-ILTLFLQVITTE 223
            :..||...|:.:|...|:||.::||..:.:|||||.||.||...:|.....| ::.|.:.....:
  Rat   118 VAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQ 182

  Fly   224 SSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWS 288
            |:.|.|..:...:.||::|||||||.||.||:|.:|.|:|:|.:...::..||||.|...|:.|:
  Rat   183 SNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWA 247

  Fly   289 IAKAFAPHLENEHFNGLEIDCAWMRES---HIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSA 350
            |.|.   |.:||.        .|..:.   :.|:|::.|..|.||:|.:||..|:.:|:||||::
  Rat   248 IGKL---HYDNEK--------CWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRAS 301

  Fly   351 HTLETRQYYKASKALLVLIPLFGITYLLVLTGP-EQGISRNLFEAIRAFLISTQGFFVALFYCFL 414
            .|.||.||.||.||.|||:||.||||:|....| |..:||.:|....:||.|.|||||::|||||
  Rat   302 TTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFL 366

  Fly   415 NSEVRQTLRHGFTRWRESRNIHRNSSIKNRSTEECVICLRPSPHTRLGSLQRYHSI 470
            |||||..:|..:.||::..      ||:.|......|   |:..||:.    :|||
  Rat   367 NSEVRSAIRKRWRRWQDKH------SIRARVARAMSI---PTSPTRVS----FHSI 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	29/64 (45%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	100/252 (40%)
Crhr1	NP_112261.1	HormR	40..111	CDD:214468	32/74 (43%)
		Important for peptide agonist binding. /evidence=ECO:0000250	99..108		2/8 (25%)
		7tm_2	116..359	CDD:278432	100/253 (40%)
		Important for antagonist binding. /evidence=ECO:0000250	280..290		5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3138
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20920
Inparanoid	1	1.050	268	1.000	Inparanoid score	I2947
OMA	1	1.010	-	-		QHG46870
OrthoDB	1	1.010	-	-		D1163977at2759
OrthoFinder	1	1.000	-	-		FOG0002345
OrthoInspector	1	1.000	-	-		mtm9081
orthoMCL	1	0.900	-	-		OOG6_103932
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840