DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and pth2rb

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_017208978.2	Gene:	pth2rb / 564876	ZFINID:	ZDB-GENE-050208-334	Length:	600	Species:	Danio rerio

Alignment Length:	461	Identity:	132/461 - (28%)
Similarity:	207/461 - (44%)	Gaps:	118/461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 CPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDN--ATRFCFPNG--------TWDHYSD- 137
            |...:|.::|||:.:.|::..:||    ....||...|  |.|.|..||        ||.:|||
Zfish    59 CSPGWDGLVCWPQGSPGTVTKVPC----PSYVYDFNHNGFAYRQCSSNGSWVSVENRTWVNYSDC 119

  Fly   138 ---------------YDRCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFK 187
                           ::|.|                    |:|..||.:||::|:||:.|...|:
Zfish   120 LRFLAPGIEKGKRDFFERLH--------------------IMYTVGYAVSFSSLLVAIFIIGYFR 164

  Fly   188 DLRCLRNTIHANLFLTYITSALLWIL---------------TLFLQVITT-------ESSQAGCI 230
            .|.|.||.||.:||::::..|:...:               |:.:..|:|       ::...||.
Zfish   165 RLHCTRNYIHMHLFVSFMLRAISIFVKDRVVYANGVLQEYDTMLMDNISTVSISPLDKTQYFGCK 229

  Fly   231 TLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAP 295
            ..|:.|.||..||::|:.||||||::|:...|.||:.....:.|||||.||:.:..|::.:|..
Zfish   230 ITVLFFIYFLATNYYWILVEGLYLHSLIFMAFFSDSKYLWGFTLIGWGVPALFVSTWAVVRATL- 293

  Fly   296 HLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLR--SAHTLETR-Q 357
                     .:..|..:...:|.||::||...|:.:|.:..:.|:.||.||:|  :|...:|| |
Zfish   294 ---------ADARCWELSAGNIKWIYQVPILTAIGLNFILFVNIVRVLATKIRETNAGRYDTRKQ 349

  Fly   358 YYKASKALLVLIPLFGITYLLVLTGPE--QGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQ 420
            |.|.:|:.|||:.:||:.|::.:..|.  .|:...|......|..|.|||||::.|||.|.||:.
Zfish   350 YRKLAKSTLVLVLVFGVHYIVFVGMPHTFTGLGWELRMYCELFFNSFQGFFVSIIYCFCNGEVQA 414

  Fly   421 TLRHGFTRWR--------------ESRNIHRNSSIKNRS------------TEECVICL-RPSPH 458
            .:|..:.||.              ...::..||...|:|            |.....|. |||
Zfish   415 EIRKTWLRWTLAFDWKGPVVLANYRYGSVLNNSGASNQSQLTSVTRSSALLTSRIYRCTSRPS-- 477

  Fly   459 TRLGSL 464
              :|||
Zfish   478 --VGSL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	23/85 (27%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	86/274 (31%)
pth2rb	XP_017208978.2	HRM	57..119	CDD:308439	20/63 (32%)
		7tmB1_PTHR	135..422	CDD:320393	97/316 (31%)
		TM helix 1	137..162	CDD:320393	12/44 (27%)
		TM helix 2	171..193	CDD:320393	6/21 (29%)
		TM helix 3	229..256	CDD:320393	13/26 (50%)
		TM helix 4	268..288	CDD:320393	8/19 (42%)
		TM helix 5	303..332	CDD:320393	8/28 (29%)
		TM helix 6	349..376	CDD:320393	10/26 (38%)
		TM helix 7	384..409	CDD:320393	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910