DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and adcyap1r1b

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_021327469.1	Gene:	adcyap1r1b / 555473	ZFINID:	ZDB-GENE-110127-1	Length:	445	Species:	Danio rerio

Alignment Length:	414	Identity:	129/414 - (31%)
Similarity:	210/414 - (50%)	Gaps:	56/414 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTD--NATRFCFPNGTWD----HYSDYDR 140
            |.|...:|::.||.....|.:..:||.|.|:.::.:..:  ..:|.|...| |.    ||.|...
Zfish    52 LVCRWMWDNLTCWQPARLGQVVWMPCPELFEVMNDENNEFGKVSRNCTEYG-WSEMVPHYVDVCP 115

  Fly   141 CHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYI 205
            .::|..:    ||.. .|.:.| :|..||..|..:|..|::|...|:.|.|.||.||.|||:::|
Zfish   116 FNENGTN----PDMY-YVSVKA-LYTVGYSTSLVSLTTAMVILCKFRKLHCTRNFIHMNLFVSFI 174

  Fly   206 TSALLWILTLFLQ--VITTESSQAGCI-------TLVIMFQYFYLTNFFWMFVEGLYLYTLVVQT 261
            ..|    :::|::  ::..|.....|.       .:::.|.|..|:|:||:|:|||||:||:|:|
Zfish   175 LRA----ISVFIKDGILYAEEDSNHCFIHTVECKAVMVFFHYCVLSNYFWLFIEGLYLFTLLVET 235

  Fly   262 FSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAW--MRESHIDWIFKVP 324
            |..:...|..|.:||||.|.:|:.:|::.:|   |.:|       |.| |  ...:.|.|:.|.|
Zfish   236 FFPEKRYFYWYTIIGWGTPTICVTIWAVLRA---HFDN-------IGC-WDINDNATIWWVIKGP 289

  Fly   325 ASLALLVNLVFLIRIMWVLITKLRSAHT--LETRQYYKASKALLVLIPLFGITYLLVLTGPEQGI 387
            ...::::|.:..|.|:.:|:.||:|...  .|:..|.:.:::.|:|||||||.|.:....||...
Zfish   290 VLASIMINFILFIGIIIILVQKLQSPDIGGNESSIYLRLARSTLLLIPLFGIHYTVFAFTPEDVS 354

  Fly   388 SRN--LFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNI-----HRNSSIK--- 442
            .|.  :||   ..|.|.|||.||:.|||||.||:..::..:..|..:|..     ||:.|:.
Zfish   355 KRERLVFE---LGLGSFQGFVVAVLYCFLNGEVQSEIKRKWRSWTVNRYFAVDMKHRHPSLASSG 416

  Fly   443 -NRSTEECVICLRPSPHTRLGSLQ 465
             |..|:..::. :.|...|:.|||
Zfish   417 VNGGTQLSILS-KSSSQIRMSSLQ 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	17/67 (25%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	87/262 (33%)
adcyap1r1b	XP_021327469.1	HRM	51..117	CDD:308439	17/65 (26%)
		7tm_GPCRs	127..394	CDD:333717	97/285 (34%)
		TM helix 1	130..154	CDD:320095	8/24 (33%)
		TM helix 2	163..184	CDD:320095	9/24 (38%)
		TM helix 3	204..226	CDD:320095	8/21 (38%)
		TM helix 4	245..261	CDD:320095	7/15 (47%)
		TM helix 5	279..302	CDD:320095	5/22 (23%)
		TM helix 6	326..351	CDD:320095	9/24 (38%)
		TM helix 7	356..381	CDD:320095	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810