DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and calcrl

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_012825895.1	Gene:	calcrl / 549647	XenbaseID:	XB-GENE-5736126	Length:	481	Species:	Xenopus tropicalis

Alignment Length:	455	Identity:	131/455 - (28%)
Similarity:	222/455 - (48%)	Gaps:	84/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIANFSVDMLQRAS-----------------ALIGAQQGS--------SGGQLQNRTL----QCQ 59
            :|..|.:.:|.|::                 .|...:|||        ..|..:|:.:    :|.
Frog     4 IIETFEMGLLLRSALFKYIIIVLIMLNLRGYVLAEQEQGSQIPLEEIIQVGVTRNKIMTAQYECY 68

  Fly    60 QQQQREEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATR 124
            |:..:|         .:.||....|..::|..|||...:||.::...|.:.|:  .:|.::..|:
Frog    69 QKIMQE---------PANGKEGHFCNRTWDGWLCWGDVSAGVISEQRCPDYFQ--DFDPSEKVTK 122

  Fly   125 FCFPNGTWDHYSD-------YDRC----HQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVV 178
            .|..||.|..:.|       |.||    |:...:       :.|:....||   |:.||.|:|::
Frog   123 ECGKNGHWFRHPDSNRTWTNYTRCNTFTHEKVKT-------ALNLYYLTII---GHGLSIASLLI 177

  Fly   179 ALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQVITTESSQAGCIT-----LVIMFQY 238
            :|.||..||:|.|.|.|:|.|||.:::.::::.|::|    ....::||...|     .:..|.:
Frog   178 SLGIFFYFKNLSCQRITLHKNLFFSFVCNSIITIISL----SAVANNQALVATNPVSCKISQFIH 238

  Fly   239 FYL--TNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEH 301
            .||  .|:|||..||:||:||:|....::....:.|.|:|||.|.:...:.::|::.       :
Frog   239 LYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYLLGWGFPLIPACIHAVARSL-------Y 296

  Fly   302 FNGLEIDCAWM-RESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKAL 365
            :|    |..|: .|:|:.:|...|...||||||.||:.|:.||||||:..|..|:..|.||.:|.
Frog   297 YN----DNCWISSETHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRAT 357

  Fly   366 LVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR 430
            |:|:||.||.::|....||..|:..:::.:...|:..||..||..:||.|.||:..|:..:.:::
Frog   358 LILVPLLGIEFVLFPWKPEGRIAEEIYDYVMHILMHYQGLLVATIFCFFNGEVQAVLKRHWNQYK 422

Fly 431 430
Frog 423 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	20/72 (28%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	87/255 (34%)
calcrl	XP_012825895.1	HRM	81..149	CDD:367186	19/69 (28%)
		7tmB1_calcitonin_R	157..429	CDD:341343	96/284 (34%)
		TM helix 1	159..184	CDD:341343	11/27 (41%)
		TM helix 2	193..215	CDD:341343	7/25 (28%)
		TM helix 3	232..259	CDD:341343	11/26 (42%)
		TM helix 4	271..291	CDD:341343	6/19 (32%)
		TM helix 5	306..335	CDD:341343	13/28 (46%)
		TM helix 6	349..376	CDD:341343	11/26 (42%)
		TM helix 7	382..407	CDD:341343	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940