DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Calcrl

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_061252.2	Gene:	Calcrl / 54598	MGIID:	1926944	Length:	463	Species:	Mus musculus

Alignment Length:	414	Identity:	127/414 - (30%)
Similarity:	211/414 - (50%)	Gaps:	50/414 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ALIGAQQ---------GSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSVLC 93
            |||.|:.         |.:..::.....:|.|:..::..|.     |.|    |.|..::|..||
Mouse    18 ALISAESEEGVNQTDLGVTRNKIMTAQYECYQKIMQDPIQQ-----AEG----LYCNRTWDGWLC 73

  Fly    94 WPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQN----SGSIPVVPDF 154
            |....||:.::..|.:.|:  .:|.::..|:.|..:|.|..:.|.:|...|    :.|.......
Mouse    74 WNDVAAGTESMQYCPDYFQ--DFDPSEKVTKICDQDGHWFRHPDSNRTWTNYTLCNNSTHEKVKT 136

  Fly   155 SPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQV 219
            :.|:....||   |:.||.|:|:::||||..||.|.|.|.|:|.|||.::|.::::.|:.|
Mouse   137 ALNLFYLTII---GHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVTIIHL---- 194

  Fly   220 ITTESSQAGCIT-----LVIMFQYFYL--TNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGW 277
            ....::||...|     .|..|.:.||  .|:|||..||:||:||:|....::....:.|..:||
Mouse   195 TAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHLMWYYFLGW 259

  Fly   278 GCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWM-RESHIDWIFKVPASLALLVNLVFLIRIMW 341
            |.|.:...:.:||::.       ::|    |..|: .::|:.:|...|...||||||.||:.|:.
Mouse   260 GFPLLPACIHAIARSL-------YYN----DNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVR 313

  Fly   342 VLITKLRSAHTLETRQYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFF 406
            ||||||:..|.:|:..|.||.:|.|:|:||.||.::|....||..::..:::.:...|:..||..
Mouse   314 VLITKLKVTHQVESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHFQGLL 378

  Fly   407 VALFYCFLNSEVRQTLRHGFTRWR 430
            ||..:||.|.||:..||..:.:::
Mouse   379 VATIFCFFNGEVQAILRRNWNQYK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	17/61 (28%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	88/255 (35%)
Calcrl	NP_061252.2	HRM	61..128	CDD:397086	19/72 (26%)
		7tmB1_calcitonin_R	137..410	CDD:341343	98/284 (35%)
		TM helix 1	140..164	CDD:341343	11/26 (42%)
		TM helix 2	173..194	CDD:341343	7/20 (35%)
		TM helix 3	212..234	CDD:341343	9/21 (43%)
		TM helix 4	253..269	CDD:341343	5/15 (33%)
		TM helix 5	286..309	CDD:341343	10/22 (45%)
		TM helix 6	334..356	CDD:341343	8/21 (38%)
		TM helix 7	362..387	CDD:341343	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840