Protein Alignment Dh44-R2 and ghrhra

DIOPT Version :10

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_001124524.1
• Gene: ghrhra / 541314
• ZFINID: ZDB-GENE-050315-2
• Length: 432
• Species: Danio rerio
• Alignment Length: 422
• Identity: 137/422 - (32%)
• Similarity: 200/422 - (47%)
• Gaps: 59/422 - (13%)

  Fly    58 CQQQQQREEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDN- 121
            |.|.::||.:..|.:.         .|.:.:|.:.||...|.|.|..:.|.:.|:  |...|..
Zfish    36 CIQTRKREIKNHSQQT---------GCGTDWDGIRCWHTANTGQLINVSCSDVFQ--HISNTQGF 89

  Fly   122 ATRFCFPNGTWDHYSDYDRC---HQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIF 183
            ..|.|..||..|.|..|:..   ..:|.|..|....|...:|    |..||..|..:|:.|:|||
Zfish    90 IYRNCVSNGWTDPYPPYEEACAFEDDSESGTVTTYLSTLKQL----YTAGYATSLISLITAVIIF 150

  Fly   184 LSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQ--VITTESSQAGCI-------TLVIMFQYF 239
            ..|:...|.||.||.|||:::|..|    ..:|::  |:.::.:|..|:       :.|..||:.
Zfish   151 TCFRKFHCTRNYIHINLFVSFILRA----SAVFIKGTVLFSDETQDHCLMSTVLCKSAVTFFQFC 211

  Fly   240 YLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNG 304
            .|||:||:.||||||.||:..||.|....|..|.|||||.|:|.::||.:.:.|   .:|.
Zfish   212 ILTNYFWLLVEGLYLQTLLALTFVSQRKYFWWYILIGWGVPSVVLVVWVLTRQF---YDNR---- 269

  Fly   305 LEIDCAW--MRESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHT--LETRQYYKASKAL 365
               .| |  ...::|.||.|.|.:.:|..|::..:.::.:|:.||:|...  .:|..:.:.:|:.
Zfish   270 ---GC-WDDTDNTNIWWIIKGPITASLFTNIIIFLNVIRILVQKLKSPGVGGNDTGHFMRLAKST 330

  Fly   366 LVLIPLFGITYLLVLTGPEQGISRNLFEAIRAF----LISTQGFFVALFYCFLNSEVRQTLRHGF 426
            |.||||||:.|.|....||     |..|.||.:    |.|.|||.|||.|||||.||:..|:...
Zfish   331 LFLIPLFGMHYTLFAFLPE-----NTGEIIRFYIELGLGSFQGFVVALLYCFLNGEVQAELKRRL 390

  Fly   427 TRWRESRNIHRNSSIKNRSTEECVICLRPSPH 458
            ..|....::   |..|.|......|.:..|.|
Zfish   391 WTWLTQTHL---SPCKKRRVTVTQIMMHESAH 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:397086	18/65 (28%)
		7tmB1_DH_R	158..428	CDD:320391	103/286 (36%)
		TM helix 1	160..185	CDD:320391	10/24 (42%)
		TM helix 2	194..216	CDD:320391	8/21 (38%)
		TM helix 3	230..257	CDD:320391	14/33 (42%)
		TM helix 4	269..289	CDD:320391	11/19 (58%)
		TM helix 5	314..343	CDD:320391	7/28 (25%)
		TM helix 6	357..384	CDD:320391	10/26 (38%)
		TM helix 7	390..415	CDD:320391	15/28 (54%)
ghrhra	NP_001124524.1	HRM	52..113	CDD:397086	18/62 (29%)
		7tmB1_GHRHR2	125..392	CDD:320399	104/290 (36%)
		TM helix 1	127..152	CDD:320399	10/28 (36%)
		TM helix 2	161..183	CDD:320399	9/25 (36%)
		TM helix 3	202..229	CDD:320399	14/26 (54%)
		TM helix 4	241..261	CDD:320399	11/19 (58%)
		TM helix 5	277..306	CDD:320399	7/28 (25%)
		TM helix 6	322..349	CDD:320399	10/26 (38%)
		TM helix 7	354..379	CDD:320399	13/24 (54%)