DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Gipr

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_006540205.1	Gene:	Gipr / 381853	MGIID:	1352753	Length:	502	Species:	Mus musculus

Alignment Length:	500	Identity:	138/500 - (27%)
Similarity:	207/500 - (41%)	Gaps:	123/500 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LIGAQQGSSGGQLQNRTLQCQQQQQR--EEEQASLEAL--ASGGKRILQCPSSFDSVLCWPRTNA 99
            |.|.|...:..:.|..|.:..|:.:.  :|.|..||..  .||    |.|..|||...||..|.|
Mouse    12 LWGLQWAETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSG----LACNGSFDMYACWNYTAA 72

  Fly   100 GSLAVLPC---FEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSGSIPVVPDFSPNVELP 161
            .:.|.:.|   ...|:.|   :.....|.|..:|.|..:.|:.:| :|........|.:..:|..
Mouse    73 NTTARVSCPWYLPWFRQV---SAGFVFRQCGSDGQWGSWRDHTQC-ENPEKNGAFQDQTLILERL 133

  Fly   162 AIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQVITTE--- 223
            .|:|..||.||..||::||:|...|:.|.|.||.||.|||.:::..|        ..::|.:
Mouse   134 QIMYTVGYSLSLTTLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRA--------AAILTRDQLL 190

  Fly   224 ----------------SSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIY 272
                            .:.|.|.|..||.||....|:.|:.|||:||:.|:|....|:...|..|
Mouse   191 PPLGPYTGDQAPTPWNQALAACRTAQIMTQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCY 255

  Fly   273 ALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLV------ 331
            .|:|||.||:.::.|.|.:....:.:....|  |:...|       ||.:.|..:.:||
Mouse   256 LLLGWGAPALFVIPWVIVRYLRENTQCWERN--EVKAIW-------WIIRTPILITILVGPVSPP 311

  Fly   332 ------------------------------------NLVFLIRIMWVLITKLRSAHTLETRQY-- 358
                                                |.:..|||:.:|::|||      |||.
Mouse   312 PGCTQGFLILGKRSANPLSHPRNRMASGSVSLSSQINFLIFIRILGILVSKLR------TRQMRC 370

  Fly   359 ----YKASKALLVLIPLFGITYLLVLTGPEQGISRNL-FE--AIRAFLISTQGFFVALFYCFLNS 416
                .:.:::.|.|:||.|:..::.....|:.:..:| |.  |...||.|.|||.|::.|||:|.
Mouse   371 PDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQVEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINK 435

  Fly   417 EVRQTLRHGFTRWRESRNIHRNSSIKNRSTEECVICLRPSPHTRL 461
            ||:..:|.|   ||     ||...:   |.:|    .||.||..|
Mouse   436 EVQSEIRQG---WR-----HRRLRL---SLQE----QRPRPHQEL 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	19/64 (30%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	85/317 (27%)
Gipr	XP_006540205.1	HRM	54..117	CDD:367186	20/70 (29%)
		7tmB1_GlucagonR-like	130..447	CDD:341353	96/347 (28%)
		TM helix 1	133..157	CDD:341353	11/23 (48%)
		TM helix 2	166..187	CDD:341353	8/28 (29%)
		TM helix 3	213..235	CDD:341353	9/21 (43%)
		TM helix 4	254..270	CDD:341353	7/15 (47%)
		TM helix 5	288..353	CDD:341353	7/71 (10%)
		TM helix 6	375..400	CDD:341353	5/24 (21%)
		TM helix 7	409..434	CDD:341353	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810