DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and mthl14

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_728509.1	Gene:	mthl14 / 318046	FlyBaseID:	FBgn0052476	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	103/510 - (20%)
Similarity:	181/510 - (35%)	Gaps:	126/510 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLD--DASQEDLAKVIANFSVDMLQRASALIGAQQGSS---GGQLQN--RTLQCQQQQQREEEQA 69
            |:|  |||......|...:|.:    |:.:.||:..:|   ...:.|  ....|.|:::..:
  Fly    50 SIDVLDASIHSTLVVPQTYSTE----AATISGARFATSVPVQSPVDNPLDPADCSQREKYRK--- 107

  Fly    70 SLEALASGGKRILQCPSSFDSVLCWPRTNAGSL--------------AVL--PCFEEFK------ 112
              :.:|:...|:.:|....:::..:....:.|:              |||  .|.|:.:
  Fly   108 --QPVATPSSRLRKCCPHGENLNIYRENQSDSMCDNGLLSFEPTIISAVLFDNCIEDLEVETTLD 170

  Fly   113 ---------GVHYDTTDNATRFCFPNGTW--------------DHYS-DYDRCHQNSG---SIPV 150
                     .:.||..|:.. |...:|:.              :||. |.|:    ||   :...
  Fly   171 YDIGNPCNSSLLYDDKDDVF-FVLQDGSLLIIDKFGNESYTVKEHYCLDIDK----SGHLFAFTC 230

  Fly   151 VPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTL 215
            |......:....:::..  .|...::...|::......||.|||....:|.|..:..|..:.:..
  Fly   231 VTQVEEQIAFAKVVFVA--VLMLISMPCLLLVSYLHMTLRLLRNLHGLSLSLMSLCLASGYFVHS 293

  Fly   216 FLQVITTESSQAGCITLVIMFQYFYLTNFFW-------MFVEGLYLYTLVVQTFSS-DNISFIIY 272
            .:.:....:.  |.|..||  |:..|:.|||       :.:...|.....:|...| ...:|..|
  Fly   294 VVHIYGIPNQ--GFIGYVI--QFCILSYFFWYLCICFNVLLNVWYKLPCCIQCSKSWATFNFACY 354

  Fly   273 ALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLI 337
            |:..:..||. |:..::.|.. |.:.:....||...   :|:|  ...|..|.|..|.  |.||:
  Fly   355 AVFAFSGPAT-IVALTVQKGL-PGMPSYFLQGLTES---IRDS--QRYFIPPVSTILF--LSFLL 410

  Fly   338 RIM----------WVLITK-LRSAHTLETRQYYKASKALLVLIPLFGI----TYLLVLTGPEQGI 387
            .|:          :....| ::....|..:|.|:..|.....:.|.||    ::||.:.....|.
  Fly   411 NIISFFGFQRISGYAKAEKNIQERKCLFDQQKYEDVKKDAKCVSLLGIIMVVSWLLEIITFYSGS 475

  Fly   388 SRNLFEAIRAFLI------STQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNIH 436
            :.|       :||      ..||.:|.|.  ||....|:|:   ..||...|..|
  Fly   476 NSN-------YLILCDMVNGLQGVWVLLI--FLVVRRRRTI---ILRWWYDRGSH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	16/107 (15%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	58/276 (21%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	65/299 (22%)
		TM helix 1	241..266	CDD:320167	2/26 (8%)
		TM helix 2	275..297	CDD:320167	3/21 (14%)
		TM helix 3	306..331	CDD:320167	8/26 (31%)
		TM helix 4	349..369	CDD:320167	6/20 (30%)
		TM helix 5	389..418	CDD:320167	10/32 (31%)
		TM helix 6	445..472	CDD:320167	6/26 (23%)
		TM helix 7	477..502	CDD:320167	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840