DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dh44-R2 and ADGRE2

DIOPT Version :10

Sequence 1:NP_610789.3 Gene:Dh44-R2 / 36368 FlyBaseID:FBgn0033744 Length:476 Species:Drosophila melanogaster
Sequence 2:XP_054176753.1 Gene:ADGRE2 / 30817 HGNCID:3337 Length:892 Species:Homo sapiens


Alignment Length:522 Identity:130/522 - (24%)
Similarity:202/522 - (38%) Gaps:108/522 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LVDSLDDASQ---EDLAKVIANFSVDMLQRASALIGAQQGSSGGQLQNRT---LQCQQQQQREEE 67
            |:|.|:|..:   ::|:..:.|||.......|..:..|...|....||:.   |...|.|:..:.
Human   402 LLDGLEDVLRGLSKNLSNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDP 466

  Fly    68 QASLEALAS---GGKRILQCPSSF--DSVLCWPRTNAGSL------------------------- 102
            ..|:..|.|   .||.:.:.|...  :..:....|:.|.|                         
Human   467 GPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLS 531

  Fly   103 ----------AVLP-----CFEEFKGVHYDTTDN-----ATRFCFPNGTWDHYSDYDRCHQNSGS 147
                      :|:|     |      |.::...|     ||..|...||.| .|...||...|..
Human   532 SPVTFTFSHRSVIPRQKVLC------VFWEHGQNGCGHWATTGCSTIGTRD-TSTICRCTHLSSF 589

  Fly   148 IPVVPDFSPNVELP--AIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALL 210
            ..::..:....|.|  .:|...|..:|...|::|.:.||..|.::....::|..|.|....:.| 
Human   590 AVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHL- 653

  Fly   211 WILTLFLQVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLY----TLVVQTFSSDN--ISF 269
                |||..|.....:..|..:.....|.||....||.:|.|||:    .|.|..:||.|  :..
Human   654 ----LFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKK 714

  Fly   270 IIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMR-ESHIDWIFKVPASLALLVNL 333
            :::. :|:|.|||.:   :|:.|..|||     .|....| |:: |....|.|..|......|||
Human   715 LMFP-VGYGVPAVTV---AISAASRPHL-----YGTPSRC-WLQPEKGFIWGFLGPVCAIFSVNL 769

  Fly   334 VFLIRIMWVLITKLRSAH----TL-ETRQY-YKASKALLVLIPLFGITYLL--VLTGPEQGISRN 390
            |..:..:|:|..:|.|.:    || .||.. :||:..|.:|    |.|:.|  :..||...:...
Human   770 VLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFIL----GCTWCLGILQVGPAARVMAY 830

  Fly   391 LFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRES-RNIHRNSSIKNRSTEECVICLR 454
            ||..|.    |.||.|:.|.||.|:.:||:.    :.:|.:. |.:...|.:...|:.......:
Human   831 LFTIIN----SLQGVFIFLVYCLLSQQVREQ----YGKWSKGIRKLKTESEMHTLSSSAKADTSK 887

  Fly   455 PS 456
            ||
Human   888 PS 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dh44-R2NP_610789.3 HRM 82..144 CDD:397086 18/108 (17%)
7tmB1_DH_R 158..428 CDD:320391 84/286 (29%)
TM helix 1 160..185 CDD:320391 7/26 (27%)
TM helix 2 194..216 CDD:320391 4/21 (19%)
TM helix 3 230..257 CDD:320391 9/30 (30%)
TM helix 4 269..289 CDD:320391 5/19 (26%)
TM helix 5 314..343 CDD:320391 9/28 (32%)
TM helix 6 357..384 CDD:320391 8/29 (28%)
TM helix 7 390..415 CDD:320391 10/24 (42%)
ADGRE2XP_054176753.1 EGF_CA 136..168 CDD:429571
EGF_CA 188..>220 CDD:214542
EGF_CA 232..263 CDD:429571
EGF_CA 281..312 CDD:429571
GPS 548..598 CDD:197639 13/56 (23%)
7tmB2_EMR 602..864 CDD:320555 84/288 (29%)
TM helix 1 604..629 CDD:320555 6/24 (25%)
TM helix 2 638..660 CDD:320555 7/26 (27%)
TM helix 3 669..696 CDD:320555 9/26 (35%)
TM helix 4 713..733 CDD:320555 6/23 (26%)
TM helix 5 750..773 CDD:320555 8/22 (36%)
TM helix 6 797..822 CDD:320555 8/28 (29%)
TM helix 7 826..851 CDD:320555 10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

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