DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Vipr2

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_058934.2	Gene:	Vipr2 / 29555	RGDID:	3962	Length:	437	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	131/424 - (30%)
Similarity:	198/424 - (46%)	Gaps:	54/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 REEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFP 128
            :|||....|.|:|..:....|...:|::.||...:.|....:||.:.|.. .|....|.::.|..
  Rat    31 QEEETKCAELLSSQMENHRACSGVWDNITCWRPADIGETVTVPCPKVFSN-FYSRPGNISKNCTS 94

  Fly   129 NGTWDHYSDY-DRCHQNSGSIPVVPDFSPNVE---LPAIIYAGGYFLSFATLVVALIIFLSFKDL 189
            :|..:.:.|: |.|..|.      |:....:.   |...||..||.:|..:|....||...|:.|
  Rat    95 DGWSETFPDFIDACGYND------PEDESKITFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKL 153

  Fly   190 RCLRNTIHANLFLTYITSAL--------LWILTLFLQVITTESSQAGCITLVIMFQYFYLTNFFW 246
            .|.||.||.||||:::..|:        |:..:..|:......|..||...::.|||..:.||:|
  Rat   154 HCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMANFYW 218

  Fly   247 MFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAW 311
            :.||||||:||:|....... .|:.|.|||||.|:|||..|...:.           .||....|
  Rat   219 LLVEGLYLHTLLVAILPPSR-CFLAYLLIGWGIPSVCIGAWIATRL-----------SLEDTGCW 271

  Fly   312 MRESHID--WIFKVPASLALLVNLVFLIRIMWVLITKLRSAHT--LETRQYYKASKALLVLIPLF 372
            ....|..  |:.::|..::::||....|.|:.:|:.||.|...  .:..||.:.:|:.|:|||||
  Rat   272 DTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLF 336

  Fly   373 GITYLLVLTGPEQGISRN---LFE-AIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR--- 430
            |:.|::....| .|||..   ||| .:.:|    ||..||:.||||||||:..|:.   |||
  Rat   337 GVHYMVFAAFP-IGISSTYQILFELCVGSF----QGLVVAVLYCFLNSEVQCELKR---RWRGLC 393

  Fly   431 ----ESRNIHRNSSIKNRSTEECVICLRPSPHTR 460
                .||:...:|...:|:..|..:.:.....|:
  Rat   394 LTQPGSRDYRLHSWSMSRNGSESALQIHRGSRTQ 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	15/62 (24%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	88/266 (33%)
Vipr2	NP_058934.2	HormR	47..117	CDD:214468	17/76 (22%)
		7tmB1_VIP-R2	122..390	CDD:320652	100/287 (35%)
		TM helix 1	125..149	CDD:320652	8/23 (35%)
		TM helix 2	158..179	CDD:320652	8/20 (40%)
		TM helix 3	202..224	CDD:320652	8/21 (38%)
		TM helix 4	242..258	CDD:320652	10/15 (67%)
		TM helix 5	276..299	CDD:320652	5/22 (23%)
		TM helix 6	326..348	CDD:320652	10/22 (45%)
		TM helix 7	353..378	CDD:320652	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810