Protein Alignment Dh44-R2 and GLP1R

DIOPT Version :9

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_002053.3
• Gene: GLP1R / 2740
• HGNCID: 4324
• Length: 463
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 130/453 - (28%)
• Similarity: 204/453 - (45%)
• Gaps: 72/453 - (15%)

  Fly    35 RASALIGAQQGSSGGQLQNRTL--------------QCQQQQQREEEQASLEALASGGKRILQCP 85
            |.:.|:....|.:|.:.|..|:              |||:....:...|:          .|.|.
Human     9 RLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPAT----------DLFCN 63

  Fly    86 SSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTW---DHYS----DYDRCHQ 143
            .:||...|||....||...:.|.............:..|||...|.|   |:.|    |...|.:
Human    64 RTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEE 128

  Fly   144 NSGSIPVVPDFSPNVEL--PAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYI- 205
            :...    ...||..:|  ..|||..||.|||:.||:|..|.|.|:.|.|.||.||.|||.::|
Human   129 SKRG----ERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFIL 189

  Fly   206 --------TSALLWILTLFLQV-----ITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTL 257
                    .:||.|:.:...|.     :.:......|..:.::.||....|::|:.|||:|||||
Human   190 RALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTL 254

  Fly   258 VVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDW--I 320
            :..:..|:...|.:|..||||.|.:.::.|.|.|..           .|.:..|.|.|::::  |
Human   255 LAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYL-----------YEDEGCWTRNSNMNYWLI 308

  Fly   321 FKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFG---ITYLLVLTG 382
            .::|...|:.||.:..:|::.::::||::....:|....:.:|:.|.||||.|   :.:..|:..
Human   309 IRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDE 373

  Fly   383 PEQGISR--NLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR-ESRNIHRNSSIK 442
            ..:|..|  .||..:.  ..|.||..||:.|||:|:||:...|..:.||| |..:|.|:||:|
Human   374 HARGTLRFIKLFTELS--FTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMK 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	19/68 (28%)
		7tm_2	159..407	CDD:278432	81/270 (30%)
GLP1R	NP_002053.3	HRM	60..128	CDD:280888	19/67 (28%)
		7tm_2	144..398	CDD:278432	80/266 (30%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:28514449	352..355		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810