DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and GCGR

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_000151.1	Gene:	GCGR / 2642	HGNCID:	4192	Length:	477	Species:	Homo sapiens

Alignment Length:	397	Identity:	126/397 - (31%)
Similarity:	183/397 - (46%)	Gaps:	53/397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRF----CFPNGTW------DHYS 136
            |.|..:||...|||.|.|.:.|.:.| ..:...|:....   ||    |.|:|.|      ..:.
Human    56 LVCNRTFDKYSCWPDTPANTTANISC-PWYLPWHHKVQH---RFVFKRCGPDGQWVRGPRGQPWR 116

  Fly   137 DYDRCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLF 201
            |..:|..:...|.|..:.:.......::|..||.||...|::||.|......|.|.||.||||||
Human   117 DASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLF 181

  Fly   202 LTYI--TSALLWILTLF-----------LQVIT--TESSQAGCITLVIMFQYFYLTNFFWMFVEG 251
            .:::  .|::|.|..|.           |.|.|  ::.:.|||....:..||..:.|:.|:.|||
Human   182 ASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEG 246

  Fly   252 LYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESH 316
            |||:.|:......:...|.:|..||||.|.:.::.|::.|..   .||       :.| |....:
Human   247 LYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCL---FEN-------VQC-WTSNDN 300

  Fly   317 ID--WIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFG---ITY 376
            :.  ||.:.|..||:|:|....:||:.:|:.|||:.....|...::.:|:.|.||||.|   :.:
Human   301 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVF 365

  Fly   377 LLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR------ESRNI 435
            ..|.....||..|:.......||.|.||..||:.|||||.||:..||..:.|||      |.||.
Human   366 AFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNT 430

  Fly   436 --HRNSS 440
              ||.||
Human   431 SNHRASS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	20/71 (28%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	83/267 (31%)
GCGR	NP_000151.1	HRM	55..122	CDD:308439	19/69 (28%)
		7tmB1_GCGR	136..410	CDD:320395	92/284 (32%)
		TM helix 1	140..165	CDD:320395	9/24 (38%)
		TM helix 2	174..196	CDD:320395	10/21 (48%)
		TM helix 3	225..252	CDD:320395	10/26 (38%)
		TM helix 4	264..284	CDD:320395	8/19 (42%)
		TM helix 5	300..329	CDD:320395	9/28 (32%)
		TM helix 6	345..370	CDD:320395	8/24 (33%)
		Allosteric inhibitor binding. /evidence=ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451	350..353		0/2 (0%)
		TM helix 7	379..404	CDD:320395	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..477		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810