Protein Alignment Dh44-R2 and Glp1r

DIOPT Version :10

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_036860.2
• Gene: Glp1r / 25051
• RGDID: 2703
• Length: 463
• Species: Rattus norvegicus
• Alignment Length: 452
• Identity: 140/452 - (30%)
• Similarity: 214/452 - (47%)
• Gaps: 65/452 - (14%)

  Fly    32 MLQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEE----------QASLEALASGGKRILQCPS 86
            :|:.|..|:|| .|.:|.:.|..|:...:..|:..|          :|.|  ||:|    |.|..
  Rat     7 LLRLALLLLGA-VGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPL--LATG----LFCNR 64

  Fly    87 SFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDH-------YSDYDRCHQN 144
            :||...|||....||...:.|.............:..|||...|.|.|       :.|...|.::
  Rat    65 TFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEES 129

  Fly   145 SGSIPVVPDFSPNVELPA--IIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYI-- 205
            ...    ...||..:|.:  |||..||.|||:.||:|..|.:||:.|.|.||.||.|||.::|
  Rat   130 KQG----ERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILR 190

  Fly   206 -------TSALLWILTLFLQV-----ITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLV 258
                   .:||.|:.:...|.     :.:.....||..:.::.||....|::|:.|||:|||||:
  Rat   191 ALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 255

  Fly   259 VQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDW--IF 321
            ..:..|:...|.:|..||||.|.:.::.|.|.|..           .|.:..|.|.|::::  |.
  Rat   256 AFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYL-----------YEDEGCWTRNSNMNYWLII 309

  Fly   322 KVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFG---ITYLLVLTGP 383
            ::|...|:.||.:..||::.::|.||::....:|....:.:|:.|.||||.|   :.:..|:...
  Rat   310 RLPILFAIGVNFLIFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEH 374

  Fly   384 EQGISR--NLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR-ESRNIHRNSSIK 442
            .:|..|  .||..:.  ..|.|||.||:.|||:|:||:...|..:.||| |..||.|:||:|
  Rat   375 ARGTLRFVKLFTELS--FTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMK 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:397086	18/68 (26%)
		7tmB1_DH_R	158..428	CDD:320391	94/292 (32%)
		TM helix 1	160..185	CDD:320391	13/26 (50%)
		TM helix 2	194..216	CDD:320391	10/30 (33%)
		TM helix 3	230..257	CDD:320391	10/26 (38%)
		TM helix 4	269..289	CDD:320391	8/19 (42%)
		TM helix 5	314..343	CDD:320391	8/30 (27%)
		TM helix 6	357..384	CDD:320391	8/29 (28%)
		TM helix 7	390..415	CDD:320391	11/24 (46%)
Glp1r	NP_036860.2	HRM	59..128	CDD:397086	19/72 (26%)
		7tmB1_GLP1R	141..419	CDD:341342	94/290 (32%)
		TM helix 1	143..168	CDD:341342	12/24 (50%)
		TM helix 2	177..199	CDD:341342	7/21 (33%)
		TM helix 3	227..254	CDD:341342	10/26 (38%)
		TM helix 4	266..286	CDD:341342	8/19 (42%)
		TM helix 5	302..331	CDD:341342	7/28 (25%)
		TM helix 6	345..372	CDD:341342	8/26 (31%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220	352..355		0/2 (0%)
		TM helix 7	381..406	CDD:341342	11/26 (42%)