DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and Glp1r

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_036860.2	Gene:	Glp1r / 25051	RGDID:	2703	Length:	463	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	140/452 - (30%)
Similarity:	214/452 - (47%)	Gaps:	65/452 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MLQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEE----------QASLEALASGGKRILQCPS 86
            :|:.|..|:|| .|.:|.:.|..|:...:..|:..|          :|.|  ||:|    |.|..
  Rat     7 LLRLALLLLGA-VGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPL--LATG----LFCNR 64

  Fly    87 SFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDH-------YSDYDRCHQN 144
            :||...|||....||...:.|.............:..|||...|.|.|       :.|...|.::
  Rat    65 TFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEES 129

  Fly   145 SGSIPVVPDFSPNVELPA--IIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYI-- 205
            ...    ...||..:|.:  |||..||.|||:.||:|..|.:||:.|.|.||.||.|||.::|
  Rat   130 KQG----ERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILR 190

  Fly   206 -------TSALLWILTLFLQV-----ITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLV 258
                   .:||.|:.:...|.     :.:.....||..:.::.||....|::|:.|||:|||||:
  Rat   191 ALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 255

  Fly   259 VQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDW--IF 321
            ..:..|:...|.:|..||||.|.:.::.|.|.|..           .|.:..|.|.|::::  |.
  Rat   256 AFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYL-----------YEDEGCWTRNSNMNYWLII 309

  Fly   322 KVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFG---ITYLLVLTGP 383
            ::|...|:.||.:..||::.::|.||::....:|....:.:|:.|.||||.|   :.:..|:...
  Rat   310 RLPILFAIGVNFLIFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEH 374

  Fly   384 EQGISR--NLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR-ESRNIHRNSSIK 442
            .:|..|  .||..:.  ..|.|||.||:.|||:|:||:...|..:.||| |..||.|:||:|
  Rat   375 ARGTLRFVKLFTELS--FTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMK 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	18/68 (26%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	85/270 (31%)
Glp1r	NP_036860.2	HRM	59..128	CDD:397086	19/72 (26%)
		7tmB1_GLP1R	141..419	CDD:341342	94/290 (32%)
		TM helix 1	144..168	CDD:341342	12/23 (52%)
		TM helix 2	177..198	CDD:341342	7/20 (35%)
		TM helix 3	227..249	CDD:341342	6/21 (29%)
		TM helix 4	268..284	CDD:341342	6/15 (40%)
		TM helix 5	302..325	CDD:341342	5/22 (23%)
		TM helix 6	350..372	CDD:341342	8/21 (38%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250\|UniProtKB:P43220	352..355		0/2 (0%)
		TM helix 7	381..406	CDD:341342	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810