DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Gipr

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_036846.1	Gene:	Gipr / 25024	RGDID:	2689	Length:	455	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	141/462 - (30%)
Similarity:	204/462 - (44%)	Gaps:	85/462 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEEQASLEAL--ASGGKRILQCPSSFDSVLCWP 95
            ||||..   ..:|.:.|:|..|     .::...|.|.:|||.  .||    |.|..|||...||.
  Rat    17 LQRAET---DSEGQTTGELYQR-----WERYGWECQNTLEATEPPSG----LACNGSFDMYACWN 69

  Fly    96 RTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSGSIPVVPDFSPNVEL 160
            .|.|.:.|.:.|................|.|..:|.|..:.|:.:| :|........|....:|.
  Rat    70 YTAANTTARVSCPWYLPWYRQVAAGFVFRQCGSDGQWGSWRDHTQC-ENPEKNGAFQDQKLILER 133

  Fly   161 PAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSA--------LLWIL---- 213
            ..::|..||.||.|||::||:|...|:.|.|.||.||.|||.:::..|        ||..|
  Rat   134 LQVVYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRAGAILTRDQLLPPLGPYT 198

  Fly   214 -----TLFLQVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYA 273
                 ||:.|.:      |.|.|..|:.||....|:.|:.|||:||:.|:|....|:...|..|.
  Rat   199 GNQTPTLWNQAL------AACRTAQILTQYCVGANYTWLLVEGVYLHHLLVVVRRSEKGHFRCYL 257

  Fly   274 LIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLIR 338
            |:|||.||:.::.|.|.:....:.:....|  |:...|       ||.:.|..:.:|:|.:..||
  Rat   258 LLGWGAPALFVIPWVIVRYLYENTQCWERN--EVKAIW-------WIIRTPILITILINFLIFIR 313

  Fly   339 IMWVLITKLRSAHTLETRQY------YKASKALLVLIPLFG---ITYLLVLTGPEQGISRNLFEA 394
            |:.:|::|||      |||.      .:.:::.|.|:||.|   :.:..|.....:|..|....|
  Rat   314 ILGILVSKLR------TRQMRCPDYRLRLARSTLTLMPLLGVHEVVFAPVTEEQAEGSLRFAKLA 372

  Fly   395 IRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNIHRNSSIKNRSTEECVICLRPSPHT 459
            ...||.|.|||.|::.|||:|.||:..:|    |.|.|..            |:|     |.||
  Rat   373 FEIFLSSFQGFLVSVLYCFINKEVQSEIR----RLRLSLQ------------EQC-----PRPH- 415

  Fly   460 RLGSLQR 466
             ||...|
  Rat   416 -LGQAPR 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	17/61 (28%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	88/273 (32%)
Gipr	NP_036846.1	HRM	55..118	CDD:280888	18/67 (27%)
Gipr	NP_036846.1	7tm_2	131..385	CDD:278432	88/274 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810