DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and Pth2r

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_644676.1	Gene:	Pth2r / 213527	MGIID:	2180917	Length:	546	Species:	Mus musculus

Alignment Length:	480	Identity:	138/480 - (28%)
Similarity:	216/480 - (45%)	Gaps:	100/480 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LIGAQQGSSGGQLQNRTLQCQQQ---QQREEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAG 100
            |:.||..|.|      |:..::|   ..:.:.|..|...|...:....|...:|.::||||...|
Mouse    21 LVRAQLDSDG------TITIEEQIVLVMKAKMQCELNITAQLQEGEGNCFPEWDGIICWPRGTVG 79

  Fly   101 SLAVLPC------FEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSGSIPVVPDFSPNV- 158
            .::.:||      |.. |||       |.|.|.||||||.....::...|.....:.||.  |:
Mouse    80 KMSAVPCPPYVYDFNH-KGV-------AFRHCTPNGTWDSIHGSNKTWANYSDCFLQPDI--NIG 134

  Fly   159 -----ELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLF-- 216
                 |...|:|..||.:||.:|.||::|...|:.|.|.||.||.:||::::..|    :::|
Mouse   135 KQEFFESLYILYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHLHLFVSFMLRA----MSIFVK 195

  Fly   217 ------------LQVITTE--------------SSQAGCITLVIMFQYFYLTNFFWMFVEGLYLY 255
                        ||.:..:              |...||...|:||.||..||::|:.||||||:
Mouse   196 DRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLH 260

  Fly   256 TLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDWI 320
            .|:..:|.||......:..||||.|||.::.|::|:|..          .:..| |...:...||
Mouse   261 NLIFVSFFSDTKYLWGFISIGWGFPAVFVVAWAVARATL----------ADTRC-WELSAGDRWI 314

  Fly   321 FKVPASLALLVNLVFLIRIMWVLITKLRSAHTL---ETRQYYKASKALLVLIPLFGITYLLVLTG 382
            ::.|...|:.:|.:..:..:.||.||:...:.:   ..:||.|.:|:.|||:.:||:.|::.:..
Mouse   315 YQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFVCQ 379

  Fly   383 PE--QGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNIHRNSSIKNRS 445
            |.  .|:...:......|..|.|||||::.||:.|.||:..::..:|||        |.||..:.
Mouse   380 PHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGEVQAEVKKMWTRW--------NLSIDWKR 436

  Fly   446 TEECVICLRPSPHTRLGSLQRYHSI 470
            ...|            |. |||.|:
Mouse   437 APPC------------GG-QRYGSV 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	22/67 (33%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	83/280 (30%)
Pth2r	NP_644676.1	HRM	63..125	CDD:280888	23/69 (33%)
		7tm_2	139..406	CDD:278432	83/281 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..546
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810