Protein Alignment Dh44-R2 and Glp1r

DIOPT Version :9

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_067307.2
• Gene: Glp1r / 14652
• MGIID: 99571
• Length: 463
• Species: Mus musculus
• Alignment Length: 455
• Identity: 137/455 - (30%)
• Similarity: 218/455 - (47%)
• Gaps: 71/455 - (15%)

  Fly    32 MLQRASALIGAQQGSSGGQLQ------NRTLQCQQQQQREEEQASLEA--LASGGKRILQCPSSF 88
            :|:.|..|:|| .|.:|.:.|      :.|:|..::.:|:.::...||  ||:|    |.|..:|
Mouse     7 LLRLALLLLGA-VGRAGPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATG----LFCNRTF 66

  Fly    89 DSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSGSIPVVPD 153
            |...|||....||...:.|.............:..|||...|.|        .|:::.|:| ..|
Mouse    67 DDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLW--------LHKDNSSLP-WRD 122

  Fly   154 FS------------PNVELPA--IIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTY 204
            .|            |..:|.:  |||..||.|||:.||:|..|.:.|:.|.|.||.||.|||.::
Mouse   123 LSECEESKRGERNFPEEQLLSLYIIYTVGYALSFSALVIASAILVGFRHLHCTRNYIHLNLFASF 187

  Fly   205 I---------TSALLWILTLFLQV-----ITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLY 255
            |         .:||.|:.:...|.     :.:.....||..:.::.||....|::|:.|||:|||
Mouse   188 ILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLY 252

  Fly   256 TLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDW- 319
            ||:..:..|:...|.:|..||||.|.:.::.|.|.|..           .|.:..|.|.|::::
Mouse   253 TLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYL-----------YEDEGCWTRNSNMNYW 306

  Fly   320 -IFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFG---ITYLLVL 380
             |.::|...|:.||.:..||::.::::||::....:|....:.:|:.|.||||.|   :.:..|:
Mouse   307 LIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVM 371

  Fly   381 TGPEQGISR--NLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWR-ESRNIHRNSSIK 442
            ....:|..|  .||..:.  ..|.||..||:.|||:|:||:...|..:.||| |..||.|:.|:|
Mouse   372 DEHARGTLRFIKLFTELS--FTSFQGLMVAILYCFVNNEVQMEFRKCWERWRLEHLNIQRDCSMK 434

  Fly   443  442
            Mouse   435  434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	16/61 (26%)
		7tm_2	159..407	CDD:278432	82/270 (30%)
Glp1r	NP_067307.2	HRM	59..128	CDD:280888	21/81 (26%)
		7tm_2	141..398	CDD:278432	82/269 (30%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220	352..355		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810