DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Gcgr

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_017169752.1	Gene:	Gcgr / 14527	MGIID:	99572	Length:	497	Species:	Mus musculus

Alignment Length:	358	Identity:	109/358 - (30%)
Similarity:	171/358 - (47%)	Gaps:	42/358 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LPCFEEFKGVHYDTTDNATRF--CFPNGTW------DHYSDYDRCHQNSGSIPVVPDFSPNVELP 161
            ||.|.. .|.:..||.:...|  |.|:|.|      ..:.:..:|..:...|.|....:......
Mouse    91 LPTFPA-PGTYLGTTKHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQ 154

  Fly   162 AIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSA-----LLWIL-------- 213
            .::|..||.||...|::||:|.|..:.|.|.||.||.|||.:::..|     :.|:|
Mouse   155 QVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKI 219

  Fly   214 --TLFLQVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIG 276
              .|.:.|..::.:.|||....::.||..:.|:.|:.|||:|||:|:.....|:...|.:|..||
Mouse   220 GDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIG 284

  Fly   277 WGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHID--WIFKVPASLALLVNLVFLIRI 339
            ||.|.:.::.|.:.|..   .||       :.| |....::.  ||.::|..||||:|....:.|
Mouse   285 WGAPLLFVIPWVVVKCL---FEN-------VQC-WTSNDNMGFWWILRIPVFLALLINFFIFVHI 338

  Fly   340 MWVLITKLRSAHTLETRQY-YKASKALLVLIPLFG---ITYLLVLTGPEQGISRNLFEAIRAFLI 400
            :.:|:.||| ||.:....| ::.:::.|.||||.|   :.:..|.....||..|:.......||.
Mouse   339 IHLLVAKLR-AHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLS 402

  Fly   401 STQGFFVALFYCFLNSEVRQTLRHGFTRWRESR 433
            |.||..||:.|||||.||:..|...:.:|:|.:
Mouse   403 SFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	12/46 (26%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	83/268 (31%)
Gcgr	XP_017169752.1	7tmB1_GCGR	149..429	CDD:320395	93/291 (32%)
		TM helix 1	154..178	CDD:320395	9/23 (39%)
		TM helix 2	187..208	CDD:320395	7/20 (35%)
		TM helix 3	238..260	CDD:320395	6/21 (29%)
		TM helix 4	279..295	CDD:320395	6/15 (40%)
		TM helix 5	313..336	CDD:320395	8/22 (36%)
		TM helix 6	358..383	CDD:320395	7/24 (29%)
		TM helix 7	392..417	CDD:320395	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810