Protein Alignment Dh44-R2 and CRHR1

DIOPT Version :9

• Sequence 1: NP_610789.3
• Gene: Dh44-R2 / 36368
• FlyBaseID: FBgn0033744
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_001138618.1
• Gene: CRHR1 / 1394
• HGNCID: 2357
• Length: 444
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 167/475 - (35%)
• Similarity: 237/475 - (49%)
• Gaps: 82/475 - (17%)

  Fly    33 LQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSV-LCWPR 96
            |.:|..|:|....|:..|.|:    |        |..||.:..||    |||.:|.|.: .||||
Human     9 LVKALLLLGLNPVSASLQDQH----C--------ESLSLASNISG----LQCNASVDLIGTCWPR 57

  Fly    97 TNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQ--NSGSIPVVPDFSPNVE 159
            :.||.|.|.||...|.||.|:||:|..|.|..||:|....:|..|.:  |......|     :..
Human    58 SPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKV-----HYH 117

  Fly   160 LPAIIYAGGYFLSFATLVVALIIFLSF-----------------------------KDLRCLRNT 195
            :..||...|:.:|...|:||.::||..                             :.:|||||.
Human   118 VAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNI 182

  Fly   196 IHANLFLTYITSALLW-ILTLFLQVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVV 259
            ||.||...:|.....| ::.|.:.....:|:...|..:...:.||::|||||||.||.||:|.:|
Human   183 IHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV 247

  Fly   260 QTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRES---HIDWIF 321
            .|:|:|.:...::..||||.|...|:.|:|.|.:   .:||.        .|..:.   :.|:|:
Human   248 LTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY---YDNEK--------CWFGKRPGVYTDYIY 301

  Fly   322 KVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFGITYLLVLTGP-EQ 385
            :.|..|.||:|.:||..|:.:|:||||::.|.||.||.||.||.|||:||.||||:|....| |.
Human   302 QGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGED 366

  Fly   386 GISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNIHRNSSIKNRSTEECV 450
            .:||.:|....:||.|.|||||::||||||||||..:|..:.||::..      ||:.|......
Human   367 EVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKH------SIRARVARAMS 425

  Fly   451 ICLRPSPHTRLGSLQRYHSI 470
            |   |:..||:.    :|||
Human   426 I---PTSPTRVS----FHSI 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	29/64 (45%)
		7tm_2	159..407	CDD:278432	98/281 (35%)
CRHR1	NP_001138618.1	HormR	40..111	CDD:214468	32/74 (43%)
		Important for peptide agonist binding	99..108		2/8 (25%)
		7tm_2	116..388	CDD:278432	98/282 (35%)
		Important for antagonist binding	309..319		5/9 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3268
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20920
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3019
Isobase	1	0.950	-	0	Normalized mean entropy	S5470
OMA	1	1.010	-	-		QHG46870
OrthoDB	1	1.010	-	-		D1163977at2759
OrthoFinder	1	1.000	-	-		FOG0002345
OrthoInspector	1	1.000	-	-		mtm8601
orthoMCL	1	0.900	-	-		OOG6_103932
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.820