DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and Crhr1

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_031788.1	Gene:	Crhr1 / 12921	MGIID:	88498	Length:	415	Species:	Mus musculus

Alignment Length:	446	Identity:	169/446 - (37%)
Similarity:	238/446 - (53%)	Gaps:	53/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSV-LCWPR 96
            |.:|..|:|....|:..|.|    ||        |..||.:..||    |||.:|.|.: .||||
Mouse     9 LVKALLLLGLNPVSTSLQDQ----QC--------ESLSLASNVSG----LQCNASVDLIGTCWPR 57

  Fly    97 TNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQ--NSGSIPVVPDFSPNVE 159
            :.||.|.|.||...|.||.|:||:|..|.|..||:|....:|..|.:  |......|     :..
Mouse    58 SPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKV-----HYH 117

  Fly   160 LPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLW-ILTLFLQVITTE 223
            :..||...|:.:|...|:||.::||..:.:|||||.||.||...:|.....| ::.|.:.....:
Mouse   118 IAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQ 182

  Fly   224 SSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWS 288
            |:.|.|..:...:.||::|||||||.||.||:|.:|.|:|:|.:...::..||||.|...|:.|:
Mouse   183 SNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWA 247

  Fly   289 IAKAFAPHLENEHFNGLEIDCAWMRES---HIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSA 350
            |.|.:   .:||.        .|..:.   :.|:|::.|..|.||:|.:||..|:.:|:||||::
Mouse   248 IGKLY---YDNEK--------CWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRAS 301

  Fly   351 HTLETRQYYKASKALLVLIPLFGITYLLVLTGP-EQGISRNLFEAIRAFLISTQGFFVALFYCFL 414
            .|.||.||.||.||.|||:||.||||:|....| |..:||.:|....:||.|.|||||::|||||
Mouse   302 TTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFL 366

  Fly   415 NSEVRQTLRHGFTRWRESRNIHRNSSIKNRSTEECVICLRPSPHTRLGSLQRYHSI 470
            |||||..:|..:.||::..      ||:.|......|   |:..||:.    :|||
Mouse   367 NSEVRSAIRKRWRRWQDKH------SIRARVARAMSI---PTSPTRVS----FHSI 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	29/64 (45%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	99/252 (39%)
Crhr1	NP_031788.1	HormR	40..111	CDD:214468	32/74 (43%)
Crhr1	NP_031788.1	7tm_2	116..359	CDD:278432	99/253 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3230
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20920
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3020
Isobase	1	0.950	-	0	Normalized mean entropy	S5470
OMA	1	1.010	-	-		QHG46870
OrthoDB	1	1.010	-	-		D1163977at2759
OrthoFinder	1	1.000	-	-		FOG0002345
OrthoInspector	1	1.000	-	-		mtm8835
orthoMCL	1	0.900	-	-		OOG6_103932
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820