DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh44-R2 and Calcr

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001363947.1	Gene:	Calcr / 12311	MGIID:	101950	Length:	533	Species:	Mus musculus

Alignment Length:	448	Identity:	132/448 - (29%)
Similarity:	202/448 - (45%)	Gaps:	98/448 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSG 146
            |.|..::|..:||..|.||:.|...|.:.|.  .:||.:..:::|..||.|..:.|.:|...|
Mouse    87 LYCNRTWDGWMCWDDTPAGATAYQHCPDYFP--DFDTAEKVSKYCDENGEWFRHPDSNRTWSN-- 147

  Fly   147 SIPVVPDF-SPNVELPAIIY---AGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITS 207
             ..:...| |..::...::|   ..|:.||.|.||.:::||..||:|.|.|.|:|.::|||||.:
Mouse   148 -YTLCNAFTSEKLQNAYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILN 211

  Fly   208 ALLWILTLFLQVITT-----------------------------------------ESSQAGCIT 231
            :::.|:.| ::|:..                                         .|....|..
Mouse   212 SIIIIIHL-VEVVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKV 275

  Fly   232 LVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPH 296
            |..:.||....|:|||..||:||:||:|....:|......|.|:|||.|.|..::.:|.:|.
Mouse   276 LHFLHQYMMSCNYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITRAL--- 337

  Fly   297 LENEHFNGLEIDCAWM-RESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYK 360
                ::|    |..|: .|:|:.:|...|..:||:||..||:.|:.||:||:|..|..|:..|.|
Mouse   338 ----YYN----DNCWLSAETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMRQTHEAESYMYLK 394

  Fly   361 ASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHG 425
            |.||.:||:||.||.:::....|...:...:::.:...||..||||||..|||.|.||:.||:..
Mouse   395 AVKATMVLVPLLGIQFVVFPWRPSNKVLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQ 459

  Fly   426 FT--------RWRESRN------------------------IH---RNSSIKNRSTEE 448
            :|        ||...|.                        .|   ||..|.|...||
Mouse   460 WTQFKIQWSQRWGRRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNPPISNNEGEE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	19/61 (31%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	88/292 (30%)
Calcr	NP_001363947.1	HRM	86..154	CDD:367186	20/71 (28%)
		7tmB1_calcitonin_R	162..472	CDD:341343	101/321 (31%)
		TM helix 1	164..189	CDD:341343	9/24 (38%)
		TM helix 2	198..220	CDD:341343	9/22 (41%)
		TM helix 3	274..301	CDD:341343	11/26 (42%)
		TM helix 4	313..333	CDD:341343	7/19 (37%)
		TM helix 5	348..377	CDD:341343	11/28 (39%)
		TM helix 6	391..418	CDD:341343	11/26 (42%)
		TM helix 7	424..449	CDD:341343	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840