DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh44-R2 and CALCRL

DIOPT Version :9

Sequence 1:	NP_610789.3	Gene:	Dh44-R2 / 36368	FlyBaseID:	FBgn0033744	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_005246289.2	Gene:	CALCRL / 10203	HGNCID:	16709	Length:	472	Species:	Homo sapiens

Alignment Length:	458	Identity:	132/458 - (28%)
Similarity:	228/458 - (49%)	Gaps:	69/458 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QQGSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPC 107
            |.|.:..::.....:|.|:..::..|.     |.|    :.|..::|..|||....||:.::..|
Human    44 QLGVTRNKIMTAQYECYQKIMQDPIQQ-----AEG----VYCNRTWDGWLCWNDVAAGTESMQLC 99

  Fly   108 FEEFKGVHYDTTDNATRFCFPNGTWDH-------YSDYDRCHQNSGSIPVVPDFSPNVELPAIIY 165
            .:.|:  .:|.::..|:.|..:|.|..       :::|.:|:.|:..   ....:.|:....||
Human   100 PDYFQ--DFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHE---KVKTALNLFYLTII- 158

  Fly   166 AGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQVITTESSQAGCI 230
              |:.||.|:|:::|.||..||.|.|.|.|:|.|||.:::.::::.|:.|    ....::||...
Human   159 --GHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHL----TAVANNQALVA 217

  Fly   231 T-----LVIMFQYFYL--TNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWS 288
            |     .|..|.:.||  .|:|||..||:||:||:|....::....:.|..:|||.|.:...:.:
Human   218 TNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHA 282

  Fly   289 IAKAFAPHLENEHFNGLEIDCAWM-RESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHT 352
            ||::.       ::|    |..|: .::|:.:|...|...||||||.||:.|:.||||||:..|.
Human   283 IARSL-------YYN----DNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQ 336

  Fly   353 LETRQYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSE 417
            .|:..|.||.:|.|:|:||.||.::|:...||..|:..:::.|...|:..||..|:..:||.|.|
Human   337 AESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGE 401

  Fly   418 VRQTLRHGFTRWR-ESRNIHRNS-SIKNRS------------TEECVICLRPSPHTRLGSLQRYH 468
            |:..||..:.::: :..|...|| ::::.|            :.:|     ||.|....|:   |
Human   402 VQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDC-----PSEHLNGKSI---H 458

  Fly   469 SID 471
            .|:
Human   459 DIE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh44-R2	NP_610789.3	HRM	82..144	CDD:280888	16/68 (24%)
Dh44-R2	NP_610789.3	7tm_2	159..407	CDD:278432	88/255 (35%)
CALCRL	XP_005246289.2	HRM	73..141	CDD:397086	17/73 (23%)
		7tmB1_calcitonin_R	149..422	CDD:341343	98/290 (34%)
		TM helix 1	152..176	CDD:341343	10/26 (38%)
		TM helix 2	185..206	CDD:341343	6/20 (30%)
		TM helix 3	224..246	CDD:341343	9/21 (43%)
		TM helix 4	265..281	CDD:341343	5/15 (33%)
		TM helix 5	298..321	CDD:341343	10/22 (45%)
		TM helix 6	346..368	CDD:341343	8/21 (38%)
		TM helix 7	374..399	CDD:341343	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840