Protein Alignment Nepl10 and Ece1

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 748
• Identity: 164/748 - (21%)
• Similarity: 277/748 - (37%)
• Gaps: 192/748 - (25%)

  Fly     7 LCSCLVALFI------PIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFE 65
            |.:||.||.|      |...:.:..|:.::.|.|:::.|..||.:|:::|||.:..|:...|...
  Rat    79 LVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHS 143

  Fly    66 RVEDQFAT---------AMVEFMESHLGENDTL-APRLIKQMRQYYKACKEDTR--KLHGNPRPE 118
            |    :.|         |:::    ||.||.|. |....|:.:.||:||..:||  :|...|..|
  Rat   144 R----WGTFSNLWEHNQAIIK----HLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLME 200

  Fly   119 --ELVNQWIL------------------HPKK---FLVY--------GLNGVFIDER-------- 144
              |.:..|.:                  |.:.   |.||        ..|.:.:|:.
  Rat   201 LIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD 265

  Fly   145 --VDVAANDS-----MRWVIQL-RMPDPADRYSDRRVLQLMRLYEEAWYSMGVVKLVEKMHQLQD 201
              ::...|:.     :.:::|| ::....|..|.|..:|.:..:|.|..::.:.         |:
  Rat   266 YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIP---------QE 321

  Fly   202 KYRAEYPVVYTWSFSELR------QEIPIPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECF-- 258
            |.|.|..:.:..:.:||:      ..:|..::.|.. :.:|.:|.:.     |.|.||||:..
  Rat   322 KRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYP-VEINESEPIV-----VYDKEYLRQVSTL 380

  Fly   259 -----RCL----------------RDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYL 302
                 :||                .|...:..|.......|...:...||.   :.|:......|
  Rat   381 INSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW---KFCVSDTENNL 442

  Fly   303 PLGMNYIYDRFIYQNREEDTSKVL-EILSTLKAAFGQYLDANRLQLTPNQLAYVRAKLEGIQIKI 366
            ...:.   ..|:.....||:..:. ||:..:|.||.:.|...: .:..:.....:.|.:.|...|
  Rat   443 GFALG---PMFVKATFAEDSKNIASEIILEIKKAFEESLSTLK-WMDEDTRRSAKEKADAIYNMI 503

  Fly   367 G--NL---PEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVN 426
            |  |.   |:|....|  |.|.:.   ...:..|.:..|....|:                  ..
  Rat   504 GYPNFIMDPKELDKVF--NDYTAV---PDLYFENAMRFFNFSWRV------------------TA 545

  Fly   427 DNVRKA-------RTSP----FYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNH 480
            |.:|||       .|.|    :|...:|.|..|...||.|.:............:|.|:|||:.|
  Rat   546 DQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTH 610

  Fly   481 AFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQ---------PF---VSLKERLADLNGL 533
            ||:.:|..:|..||..| ..:....:.|:...:|..:|         |.   .:|.|.:||..||
  Rat   611 AFDDQGREYDKDGNLRP-WWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGL 674

  Fly   534 QLAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIAHD---RDDE----- 590
            :.||.|:......:...:..|   ....|:.|||.|.:||.:|....|..:|:   .|..
  Rat   675 KAAYRAYQNWVKKNGAEQILP---TLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF 736

  Fly   591 RVNVSVGNLRQFAYDFNC----ETSPSSVCEMW 619
            ||..|:.|.::|:..|.|    ..:|...||:|
  Rat   737 RVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	148/691 (21%)
Ece1	XP_006239337.1	M13	118..767	CDD:341056	150/705 (21%)