Protein Alignment Nepl10 and MMEL1

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 722
• Identity: 173/722 - (23%)
• Similarity: 286/722 - (39%)
• Gaps: 177/722 - (24%)

  Fly    32 IHNNLNRTTSPCTNFWNFACGRF-------SSASKYVDNFERVEDQFATAMVEFMESHLGENDTL 89
            |..|::.||.||.:|:.||||.:       .:.|:| ..|:.:.|:     :|.:...:.||.|.
Human   101 ILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRY-SIFDVLRDE-----LEVILKAVLENSTA 159

  Fly    90 APR-LIKQMRQYYKACKEDT--RKLHGNP----------------RPEELVN-QWILHPKKFLVY 134
            ..| .:::.|..|::|...:  .|....|                |..|.|. :|.|..:..|
Human   160 KDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLAL-- 222

  Fly   135 GLNGVFIDERVDVAA---ND---SMRWVIQLRMPD---PADRY-----SDRRV----LQLM---- 177
             :|..| :.||.:..   ||   |.|.:|.:..|.   |:..|     |:|:|    ||.|
Human   223 -MNSQF-NRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVA 285

  Fly   178 -RLYEEA-------WYSMGVVKLVEKMHQL------QDKYRAEYPVVYTWSFSELRQEI------ 222
             .|.|:|       .....:|:::|...||      |::......:.:.....||:.:.
Human   286 TLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFN 350

  Fly   223 ------PIPHSFFIELL--------GVNHTEELYHL--TFEVSDVE-YLRECFRCLRD----FAS 266
                  .:..|..|:||        |:.:.:.|.::  |:....:: ||  .:|.:.|    .:.
Human   351 WTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYL--VWRLVLDRIGSLSQ 413

  Fly   267 EPKDTYIRARQYV---LVEESEPRERNPRSCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEI 328
            ..|||.:..|:.:   :|||...||     |:.::.:.:...:..:|.|..:..  :..|.|.|:
Human   414 RFKDTRVNYRKALFGTMVEEVRWRE-----CVGYVNSNMENAVGSLYVREAFPG--DSKSMVREL 471

  Fly   329 LSTLKAAFGQYLDANRLQLTPNQLAYV--------RAKLEGIQIKIGNLPE---EKSPEFYNNHY 382
            :..::..|.:.||         :|.::        :.|...|:.:||: |:   |:.....:..|
Human   472 IDKVRTVFVETLD---------ELGWMDEESKKKAQEKAMSIREQIGH-PDYILEEMNRRLDEEY 526

  Fly   383 GSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVNDN---VRKARTSPFYENERNT 444
            .:.|||...:..|         .|||..:.|:.|...||. .|:.|   :..|..:.||...||.
Human   527 SNLNFSEDLYFEN---------SLQNLKVGAQRSLRKLRE-KVDPNLWIIGAAVVNAFYSPNRNQ 581

  Fly   445 ITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFR 509
            |..|...||.|.|...:........:|.|:|||:.|.|:..|..||..||........ .::.||
Human   582 IVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNF-STQHFR 645

  Fly   510 DAIKC------------AEEQ---PFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQ 559
            :..:|            |:||   .|.:|.|.:||..|::.||.|:.....:..:.:..|   ..
Human   646 EQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLP---GL 707

  Fly   560 EFTAPQLFHLSYAQFFCGSLPPVIA--------HDRDDERVNVSVGNLRQFAYDFNCETS----P 612
            :.|..|||.::|||.:|||..|..|        |.....||..|:.||..||..|:|...    |
Human   708 DLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHP 772

  Fly   613 SSVCEMW 619
            ...|.:|
Human   773 KERCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	165/696 (24%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	167/708 (24%)