Protein Alignment Nepl10 and Nep4

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Alignment Length: 834
• Identity: 165/834 - (19%)
• Similarity: 274/834 - (32%)
• Gaps: 289/834 - (34%)

  Fly    24 INVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKY------VDNFERVE-------------- 68
            |.:..:..:...::....||.:|:.:|||.:......      .|.||.:.
  Fly   258 IRMTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKN 322

  Fly    69 -------------------------------DQFATAMVEFMESHLGENDTLAPRLIKQMRQYYK 102
                                           ||.|....|.:..|:.....|..|::.:.::|..
  Fly   323 TPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTN 387

  Fly   103 ACKEDTRKLHGNPR--------------PEELV-----NQWILH-PKKFL------------VY- 134
            ..|.  ::|...||              |::..     |:..|| |..||            :|
  Fly   388 GTKR--KRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYR 450

  Fly   135 -----------GL--------------------------------------NGVFIDERVDVAAN 150
                       ||                                      |.:.|.:.|.....
  Fly   451 SCVNSAVLAKRGLEPLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIK 515

  Fly   151 DSMRWVIQLRMPD---PADRY----SDRRVLQLMRLY-EEAWYSMG------------------- 188
            :|...::|.....   |...|    |:.:.||..:.| .|..:.||
  Fly   516 NSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQ 580

  Fly   189 -------------VVKLVEKMHQLQDKYRAEYPVVYTWSFSELRQEIPIPHSFFIELLGVNHTEE 240
                         |.||.::|  ..|:.:|..|.:...::.:..|:        .|:||   |||
  Fly   581 LAGITAPAEQRLNVTKLYKRM--TLDQLQAVVPEIKWRAYLQSLQD--------REVLG---TEE 632

  Fly   241 LYHLTFEVSDVEYLRECFRCLRDFASEPKDT-------YIRAR------QYVLVEES-----EPR 287
            :.     :..|||:.:....|.:  ::|:..       ::|.|      ::..:::|     ..|
  Fly   633 VV-----IYAVEYMSKLVTLLDE--TDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGR 690

  Fly   288 ERNP---RSCIHHMRAYLPLGMNYIY-DRFIYQNREEDTSKVLEILSTLKAAFGQYL-DANRLQL 347
            |.:|   :.||..:...:.:.:..:: .|:...|.:.||   |.:...|:.||...| ..:.|..
  Fly   691 EESPQRWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDT---LRMTHDLQQAFRDILKTTDWLDD 752

  Fly   348 TPNQLAYVRAKLEGIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLL 412
            |..|||  ..|:..:.:|||......:|...|:.|.........:..|.|.......:.:.|.|.
  Fly   753 TTKQLA--EEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLH 815

  Fly   413 ARNSRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSL----LGAV 473
            .|.::       .|.....|..:.:|...:|.|..|...|| |.|.||.   |..||    :|.|
  Fly   816 ERVNK-------TNWQTAPAIVNAYYSRNKNQIMFPAGILQ-PPFYHRH---FPKSLNFGGIGVV 869

  Fly   474 LGHEMNHAFEQEGILFDAAGN------ESPVGLEIRESKPFRDAIKC---------AEEQPFV-- 521
            :|||:.|.|:.:|.|||..||      :|.:       :.|.:..:|         .||...|
  Fly   870 IGHELTHGFDDKGRLFDRNGNIHKWWTDSSI-------RGFDERARCIIAQYSNYTVEEVGIVLN 927

  Fly   522 ---SLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQE------FTAPQLFHLSYAQFFCG 577
               :..|.:||..||:.|:.|:      .|..:..|.....|      .|.||||.|::.|.:||
  Fly   928 GESTQGENIADNGGLRQAFHAY------QRWLKEHPSEVSDEILPGLNMTGPQLFFLNFGQVWCG 986

  Fly   578 SLPP--------VIAHDRDDERVNVSVGNLRQFAYDFNC----ETSPSSVCEMW 619
            ::.|        ...|.....||..::.|...||.:|||    ..:|...|.:|
  Fly   987 AMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	159/800 (20%)
Nep4	NP_650904.3	M13	274..1038	CDD:341056	162/814 (20%)