Protein Alignment Nepl10 and Nep2

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 754
• Identity: 158/754 - (20%)
• Similarity: 257/754 - (34%)
• Gaps: 229/754 - (30%)

  Fly    26 VATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDN------FERVEDQFATAMVEFMESHLG 84
            :.|::.:...:.....||.||:.||||.:.......|:      |..:.|:....:.:.:.:...
  Fly    90 IHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQLKDIITAERP 154

  Fly    85 ENDTLAPRLIKQMRQYYKACKEDTRKLHGNPRP----EELVNQWIL----------------HPK 129
            |.:   |:..:.....||||...|......|.|    .|.:..|.|                ..|
  Fly   155 ETE---PKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNADDSWTWQEQVK 216

  Fly   130 KFLVYGLN-GVFIDERVDVAANDSMRWVIQLRMPDPADRYSDRRVLQLMRLYEEAWYSMGVVK-L 192
            ||...|.: ...||..:.|...:|.:.:|.|          |:..|.|.|.|        :|| .
  Fly   217 KFRTAGFSMDYIIDFSIGVDLQNSTKRLIDL----------DQSSLALSREY--------LVKGF 263

  Fly   193 VEKMHQLQDKYRAEYPVVYTWSFSELRQEIPIPHSFFIELLGVN-------HTEELYHLTFE--- 247
            .|.:.....||..:..|::..:....:.|:.:...|.:.|..::       ::.|||:|...
  Fly   264 NETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQL 328

  Fly   248 ------VSDVEY----LRECFRCLRD-----------------FASEPK---DTYI--------- 273
                  |..|:|    |.|......|                 .|..||   ..|:
  Fly   329 QAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFSV 393

  Fly   274 ---------RARQYVLV----EESEPRERNPRSCIHHMRAY-------------LPLGMNYIYDR 312
                     |..||...    :|.|.|.   :.|:....:.             :.:|..|:...
  Fly   394 GFLSEEFRKRQLQYATALSGRQEQEARW---KECVDIATSSMDEVCEDDFDSLGISVGSLYVGKH 455

  Fly   313 FIYQNREEDTSKVLEILSTLKAAFGQYLD-ANRLQLTPNQLAYVRAKLEGIQIKIG----NLPEE 372
            |    .::..:..||:::.::..|...|| .|.:.....:.|  :.||..:...||    .|..|
  Fly   456 F----HKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEA--KLKLHSMATHIGYPDEMLDNE 514

  Fly   373 K----------SPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVND 427
            |          .|:.|...:...|...|::..|.|.             |..|....:||
  Fly   515 KLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLR-------------LPVNKTDWVRH----- 561

  Fly   428 NVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAA 492
             .|.|..:.||.:..|:|..|...||...|:.:.........:|.|:|||:.|.|:.:|..||..
  Fly   562 -ARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVK 625

  Fly   493 GNESPVGLEIRE------SKPFRDAIKCAEEQPFVSLKER---------------LADLNGLQLA 536
            ||       :|:      .|.:....||..|| :.:..||               :||..|::.:
  Fly   626 GN-------LRDWWHPDTQKAYLAKAKCIIEQ-YGNYTERATGLNLNGINTQGENIADNGGVKES 682

  Fly   537 YDAFFGLAHDSRQFEYRPYAFEQ---------EFTAPQLFHLSYAQFFCG-----SLPPVI---A 584
            |.|            ||.:|.:.         ::|..|:|.::..|.:|.     ||...|   .
  Fly   683 YIA------------YRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGV 735

  Fly   585 HDRDDERVNVSVGNLRQFAYDFNC-ETSPSS---VCEMW 619
            |...:.||..|:.|::.||.||:| |.||.:   .||:|
  Fly   736 HSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	150/722 (21%)
Nep2	NP_001246914.1	M13	104..772	CDD:341056	154/736 (21%)