Protein Alignment Nepl10 and KEL

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 147/735 - (20%)
• Similarity: 273/735 - (37%)
• Gaps: 179/735 - (24%)

  Fly     5 LLLCSCLVALFIPIQAIVDINVATS--NDIHNNL----NRTTSPCTNFWNFACGRFSSASKYVDN 63
            ||||.. |.||...|........||  .|:.::.    |.:.:|||:|::|||||   |.:..::
Human    69 LLLCFS-VLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGR---AKETNNS 129

  Fly    64 FERVEDQFATAMVEFMES----HLGENDTLAPRLIKQMRQYYKACKEDTRKLH--GNPRPEELVN 122
            |:.:..:....:...:|.    |.|..:       ::..|:|.:|. ||..:.  |.....:::.
Human   130 FQELATKNKNRLRRILEVQNSWHPGSGE-------EKAFQFYNSCM-DTLAIEAAGTGPLRQVIE 186

  Fly   123 Q---WILHPK----KF-----LVYGLNGVFIDERVDVAANDSMRW--VIQLRMPD---PADRYSD 170
            :   |.:..|    .|     |:....|.|...|..:..:.:...  |||:..|:   |..:..:
Human   187 ELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE 251

  Fly   171 RRV-LQLMRLY-------------------EEAWYSMGVV-KLVEKMHQLQDKYRAEYPVVYTWS 214
            ::: .|:.|.|                   |.:..|:.:. :|.:.:..|:.: ||:..:....:
Human   252 QKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQR-RAQGKLFQMVT 315

  Fly   215 FSELRQEIP-------IPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDFASEPKD-- 270
            ..:|::..|       :..:|  ..:.::.::.|.     |.|||||:...:.:.:...:.:|
Human   316 IDQLKEMAPAIDWLSCLQATF--TPMSLSPSQSLV-----VHDVEYLKNMSQLVEEMLLKQRDFL 373

  Fly   271 ------------------TYIRARQYVL-----VEESEPRERNPR--SCIHHMRAYL--PLGMNY 308
                              .:..||:.:.     :.|..|....||  .|:.....:.  .|...:
Human   374 QSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALF 438

  Fly   309 IYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQLTP--NQLAYVRA--KLEGIQIKIGNL 369
            :.:.|....|    |..:::.:.::.|.     ..||:..|  |:.....|  |:..:|:::|..
Human   439 VREAFGPSTR----SAAMKLFTAIRDAL-----ITRLRNLPWMNEETQNMAQDKVAQLQVEMGAS 494

  Fly   370 PEEKSPEFYNNHYGSANFSATNFLANLLEAF-ALRTRLQNAGLLA------RNSRVDLRHYY-VN 426
            .....||.....|..... .::||.::|... :||.|:..:.|..      :.|..|:..|| |:
Human   495 EWALKPELARQEYNDIQL-GSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVS 558

  Fly   427 DNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDA 491
            |:|               :..|...||.|.|.............|:::.||:.|.|.|  :|.
Human   559 DHV---------------VVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQ--LLL-- 604

  Fly   492 AGNESPVGLEIRESKPFRDAIKCAEEQ----PF---------VSLKERLADLNGLQLAYDAFFGL 543
                 |.|....::...::|..|.:..    |.         ::..|..||:.||.:|..|:
Human   605 -----PGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAY--- 661

  Fly   544 AHDSRQFEYRPYAF--EQEFTAPQLFHLSYAQFFCGSLPPVIAHDRDDE---RVNVSVGNLRQFA 603
              ..|...:.....  ..:.:..|:|..||||..|....|..:||....   ||:..:.:...||
Human   662 --SKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFA 724

  Fly   604 YDFNCE----TSPSSVCEMW 619
            ..|.|.    .:|||.|::|
Human   725 RYFRCARGALLNPSSRCQLW 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	129/676 (19%)
KEL	XP_005250050.1	M13	109..742	CDD:341056	133/690 (19%)