Protein Alignment Nepl10 and Mmel1

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001101467.2
• Gene: Mmel1 / 313755
• RGDID: 1309299
• Length: 774
• Species: Rattus norvegicus
• Alignment Length: 741
• Identity: 170/741 - (22%)
• Similarity: 281/741 - (37%)
• Gaps: 185/741 - (24%)

  Fly     9 SCLVALFIPIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRF-------SSASKYVDNFER 66
            ||::|               :..|..|::::..||.||:.:|||.:       .:.|:| ..|:.
  Rat    89 SCVIA---------------AARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETNSRY-SVFDI 137

  Fly    67 VEDQFATAMVEFMESHLGENDTLAPR-LIKQMRQYYKAC-------KEDTRKL-------HGNPR 116
            :.|:     :|.:...:.|:.::..| .:::.:..|::|       |.|:..|       .|.|.
  Rat   138 LRDE-----LEVILKGVLEDSSVQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLNVLDMIGGWPV 197

  Fly   117 PEELVNQ-----WILHPKKFLVYGLNGVFIDERVDVAA---ND---SMRWVIQLRMPD---PADR 167
            ..:..|:     |.|. ::..|  ||..| :.||.:..   ||   |.|.||.:..|.   |:..
  Rat   198 AMDKWNETMGPKWELE-RQLAV--LNSQF-NRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSRE 258

  Fly   168 Y----SDRRVLQLMRLYEEAWYSM--------GVVKLV-EKMHQL-------------QDKYRAE 206
            |    ...||.:....:..:..:|        |...|| |:|.|:             |:|....
  Rat   259 YYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHLANATVPQEKRHDV 323

  Fly   207 YPVVYTWSFSELRQEIPIP------------HSFFIELL--------GVNHTEELYHLTFEVSDV 251
            ..:.:.....||::...:.            .|..:|||        |:.:.|.|.    |:.||
  Rat   324 TALYHRMGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYLENLE----EIIDV 384

  Fly   252 -------EYLRECFRCLRDFA-------SEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYL 302
                   .||  .:|.:.|..       .|.:..|.:|.....:||...||     |:.::.:.:
  Rat   385 FPAQTLQNYL--VWRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRE-----CVSYVNSNM 442

  Fly   303 PLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLD-ANRLQLTPNQLAYVRAKLEGIQIKI 366
            ...:..:|.:..:.  ::..|.|.|::..:::.|...|| .|.:.....:.|  :.|...|:.:|
  Rat   443 ESAVGSLYIKRAFS--KDSKSIVSELIEKIRSVFVDNLDELNWMDEESKKKA--QEKALNIREQI 503

  Fly   367 GNLPE---EKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVNDN 428
            | .|:   |.:....:..|.|..||...:..|         .|||....|:.|...||. .|:.|
  Rat   504 G-YPDYILEDNNRHLDEEYSSLTFSEDLYFEN---------GLQNLKNNAQRSLKKLRE-KVDQN 557

  Fly   429 ---VRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFD 490
               :..|..:.||...||.|..|...||.|.|...:........:|.|:|||:.|.|:..|..||
  Rat   558 LWIIGAAVVNAFYSPNRNLIVFPAGILQPPFFSKDQPQALNFGGIGMVIGHEITHGFDDNGRNFD 622

  Fly   491 AAGNESPVGLEIRESKPFRDAIKC------------AEEQ---PFVSLKERLADLNGLQLAYDAF 540
            ..||........ .::.||...:|            |:.|   .|.:|.|.:||..|::.||.|:
  Rat   623 KNGNMLDWWSNF-SARHFRQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAY 686

  Fly   541 FGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIA--------HDRDDERVNVSVG 597
            .....:..:.:..|   ....|..|||.::|||.:|||..|..|        |.....||..|:.
  Rat   687 LQWLAEGGRDQRLP---GLNLTYAQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQ 748

  Fly   598 NLRQFAYDFNCETS----PSSVCEMW 619
            ||..|:..|:|...    |.:.|.:|
  Rat   749 NLPGFSEAFHCPRGSPMHPMNRCRIW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	161/692 (23%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
		M13	106..772	CDD:341056	163/705 (23%)