Protein Alignment Nepl10 and Kel

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_115929.3
• Gene: Kel / 23925
• MGIID: 1346053
• Length: 713
• Species: Mus musculus
• Alignment Length: 756
• Identity: 149/756 - (19%)
• Similarity: 283/756 - (37%)
• Gaps: 217/756 - (28%)

  Fly     3 CLLLLCSCLVALFI-----------PI-QAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFS 55
            |.|||.|.::..:|           |: ..::|..:|:.       ||:.:|||:|::|||.:.:
Mouse    36 CGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHYLASG-------NRSVAPCTDFFSFACEKAN 93

  Fly    56 SASKYVDNFERVEDQFATAMVEFMES----HLGENDTLAPRLIKQMRQYYKACKE-DTRKLHGNP 115
            ..|   |:|:.:.::..:.:...:|:    |||..:       ::..|:|.:|.: |..:..|:.
Mouse    94 GTS---DSFQALTEENKSRLWRLLEAPGSWHLGSGE-------EKAFQFYNSCMDTDAIEASGSG 148

  Fly   116 RPEELVNQ---WILHPKKFLVYGLNGVFIDERVDVAANDSMRWVIQ-----------LRMPDPAD 166
            ...:::.:   |          .:.|.:    ..:..|.::|.::.           || |.||.
Mouse   149 PLIQIIEELGGW----------NITGNW----TSLDFNQNLRLLMSQYGHFPFFRAYLR-PHPAP 198

  Fly   167 RYSDRRVLQ---------LMRLYEEAWYSMGVVKLVEKMHQL---------QDKYRAEYPVVYT- 212
            .::.  ::|         |.:..|:..|:..:.:.|..:::|         :.:..|.:.:|:|
Mouse   199 PHTP--IIQIDQPEFDILLQQEQEQKVYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTS 261

  Fly   213 --WSFSELRQEIPIPHSFFIELLGVNHTEEL--------------------YHLTFEVSDVEYLR 255
              :.|...:|:.......| .::.::..:|:                    ...|..|.|::|||
Mouse   262 RLFQFLRPQQQQQAQDKLF-HVVTIDELQEMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLR 325

  Fly   256 ECFRC-------------------LRDFASEPKDT-YIRARQYVLVEESEPRERNP-------RS 293
            ...:.                   |.|..|...|| :..||:.::.|..:.:||.|       ..
Mouse   326 NMSQLVEEGLLNHRESIQSYMILGLVDTLSPALDTKFQEARRELIQELRKLKERPPLPAYPRWMK 390

  Fly   294 CIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQLTPNQLAYVRA- 357
            |:....|:....:..::.|..:....:  |..:|:.:.:|       ||..::|  .:|:::..
Mouse   391 CVEQTGAFFEPTLAALFVREAFGPSIQ--SAAMELFAEIK-------DAVIIRL--KKLSWISEE 444

  Fly   358 -------KLEGIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARN 415
                   ||..:|:::|.......|:.....|..... ..:||.:.|...        ..|.|||
Mouse   445 TQKEALNKLAQLQVEMGAPKRAVKPDIATQEYNDIQL-GPSFLQSFLSCV--------RSLRARN 500

  Fly   416 SRVDLRHYYVNDNVRKARTSP-----FYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLG 475
            .:..|:.:    ...:.:.||     :|....:.:..|...||.|.|.............|:::.
Mouse   501 VQSFLQPF----PYHRWQKSPWEVNAYYSISDHMVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMA 561

  Fly   476 HEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQ------PFVS-------LKERL 527
            ||:.|.|.|  :|.       |.|....::...::|:.|.|..      |.:|       |.|..
Mouse   562 HELLHIFYQ--LLL-------PGGCPACDTHVLQEALLCLERHYAAFPLPSISSFNGSHTLLENA 617

  Fly   528 ADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAP-------QLFHLSYAQFFC---GSLPPV 582
            ||:.|:.:|:.|:     ..|..|:     ..|.|.|       |||..||||..|   .|..|.
Mouse   618 ADIGGVAIAFQAY-----SKRIVEH-----TGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQDPQ 672

  Fly   583 IAHDRDDERVNVSVGNLRQFAYDFNCE----TSPSSVCEMW 619
            ..|.....||:..:.|...||..|:|.    .:||:.|::|
Mouse   673 DPHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNPSARCKLW 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	133/689 (19%)
Kel	NP_115929.3	M13	78..711	CDD:341056	136/703 (19%)