Protein Alignment Nepl10 and nep-20

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001317749.1
• Gene: nep-20 / 188176
• WormBaseID: WBGene00020293
• Length: 834
• Species: Caenorhabditis elegans
• Alignment Length: 711
• Identity: 139/711 - (19%)
• Similarity: 237/711 - (33%)
• Gaps: 208/711 - (29%)

  Fly     7 LC---SCLVALFIPIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFERVE 68
            ||   .|:...| .:.|..|.:|              |.|.||:...||::    |:....::..
 Worm   214 LCESPQCITLAF-ELSAYQDTSV--------------SKCHNFYKATCGKY----KHHQALDKHR 259

  Fly    69 DQFATAMV-----EFM---ESHLGENDTLAPRLI-------KQMRQYYKACKEDTRKLHGNPRPE 118
            |.....:|     ||:   ||.:......|.||:       .|.:.|....| |..|:  .|.|
 Worm   260 DAKKKEVVKRIVREFLRRNESSITSKFEPAIRLMFGKCNKFSQNKTYLDIFK-DIEKI--GPWP- 320

  Fly   119 ELVNQWILHPKKFLVYGLNGVFIDERVDVAANDSMRWVIQLR--------MPDPADRYSDRRVLQ 175
            .|.:.|:     .:::.||. ::...|::...|...:.::.|        :..|:::   ::..|
 Worm   321 VLKSDWV-----DVMFNLND-YLLSLVELGFTDFGLFKLEFRQLAFGQFPVIAPSEQ---KQGNQ 376

  Fly   176 LMRLYEEAWYSMGVVKLVEKMHQLQDKYRAEYPVVYTWSFSELRQEIPIPHSFFIELLGVNHTEE 240
            |.::..|...:.|    |:...|...||..||        ||.:                   .:
 Worm   377 LEKIILEILEANG----VQADRQKLSKYLREY--------SEFK-------------------SQ 410

  Fly   241 LYHLTFEVSDVEYLRECFRCLRDFAS------EPKDT----YIRARQYVLVEESEP--------- 286
            |.|::.|.:.|:|:|.....|....|      .|..|    ..|.:..:|:..|..
 Worm   411 LRHMSLEGTSVKYIRYNASTLSVNISALVQKMAPMSTSSGLVRRIQSGILITNSSSFFGKNLDAI 475

  Fly   287 -RERNPRSCI-----------------------HHMRAYLPLG-MNYIYDRFIYQNREEDTSKVL 326
             ::.:.|:..                       |.:...||.| :..:...|:   .|||...::
 Worm   476 IQQTHKRTLANYLIFHFIDAVTFDLTSGAKHSEHTLIDLLPRGSLQVLSQDFV---DEEDQGVMV 537

  Fly   327 EILSTLK------AAFGQYLDANRLQLTPNQLAYVRAKLEGIQIKIGNLPEEKSP-EFYNNHYGS 384
            |:...||      .:.|..||...|.....:...:..|::.|      |...|.| |..|.::..
 Worm   538 EMAKDLKKHVVEMISEGSSLDKGHLVFEEKERRKLIRKVQDI------LVVTKYPLEILNQNFEK 596

  Fly   385 ANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVND---NVRKARTSPFYENERNTIT 446
            .|.:.::.|..:::.            |.|.....|..|...|   ..:....|..||...|.:.
 Worm   597 LNLTYSDSLHKIIQK------------LRRFRSEQLIEYLGGDLDPTDKGMWGSAHYEQATNDLI 649

  Fly   447 VPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDA 511
            :....:..|.||...........:|.::..|:..:.:...|..|..|: :...|:....|.|.:.
 Worm   650 IIAPIIDGPYFDTSYPNYVNIFFMGFIISRELGRSLDSVRIRKDEKGH-TENWLKSESLKRFDNN 713

  Fly   512 IKC-------------------AEEQPFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAF 557
            :||                   ..|..|::||:...::||.         :....|.:|  ....
 Worm   714 VKCWRKKITGTRFLNEMLADHVGHEASFMALKKWEKEMNGT---------IVEKIRGYE--SMTM 767

  Fly   558 EQEFTAPQLFHLSYAQFFC-------GSLPPVIAHDRDDERVNVSVGNLRQFAYDFNCETS 611
            ||.|     |||. |.:||       |.|....|......|||.:..|:.|||..|.|.::
 Worm   768 EQIF-----FHLQ-ALYFCRPPGGSTGELTAKDARQHYSTRVNEAFKNMPQFAKAFGCSSN 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	131/669 (20%)
nep-20	NP_001317749.1	PHA02030	<71..139	CDD:222843
		GluZincin	238..832	CDD:472708	131/672 (19%)