Protein Alignment Nepl10 and nep-2

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 775
• Identity: 168/775 - (21%)
• Similarity: 286/775 - (36%)
• Gaps: 231/775 - (29%)

  Fly     5 LLLCSCLVALFIPIQAIVDI-----NVATSNDIHNNLNRTTSPCTNFWNFACGRFSSA------S 58
            ||:....:..:|..:...|:     .:.|::.|.:::|.:..||.:|:.||||::...      :
 Worm    33 LLVLGAAIYFYINYKDSSDVCLSPGCIKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDA 97

  Fly    59 KYVDNFERVEDQFATAMVEFMESHLGEND------TLAPRLIKQMRQYYKACKEDTRKLHGNPRP 117
            ..|.|||.:......|:.|.::    |||      |.|   :.:.:.:|..|..::
 Worm    98 PSVSNFENLGQDLEFALKELLD----ENDEPYDYETSA---VGKAKYFYNLCLNES--------- 146

  Fly   118 EELVNQW----------------ILHPKKFLVYGLNGVFIDERVDVAANDSMRWVIQLRMPDPAD 166
             |:::.|                :.|..| ....:..::.|......|:...:..:|     |.|
 Worm   147 -EILDNWRTTFDEVVKSFGGWPSLGHQMK-PDASIEMLYADMVAKFKADSLFKATVQ-----PDD 204

  Fly   167 RYSDRRVLQL----MRLYEEAWYSMGVVKLVEKMHQLQ--------------------------- 200
            :.|.|.||.:    :.|:...:|.  ..:..|:|..||
 Worm   205 KNSQRHVLLIDQPQLNLFARDFYV--AAENEERMAYLQLIRDVLILLDADRTRATLDAKEIIDFE 267

  Fly   201 ---------DKYRAEYPVVYT-WSFSELRQEIPIPH----SFFIELLGVNHTEELYHLTFEVSD- 250
                     |::|.:...:|| .:..|:|:.  :||    .||..:....|.:....:||:.:.
 Worm   268 TALANITMADEHRHDIAELYTKITLGEMRRS--LPHFNWPLFFNRMFKDLHEKNGKRITFDDNTE 330

  Fly   251 ------------------------VEYLRECF---RCLRDFASEPKDTYIRARQYVLVEESEPRE 288
                                    |.||..|:   ..|||.......|..:.  |..:.....::
 Worm   331 VVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKF--YKTLNIMNVQK 393

  Fly   289 RNPRSCIHHMRAYLPLGMNYIY--DRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQLTPNQ 351
            .....|:..:.:.:|:..:.||  :.|.::.:::    |.|::|.:..:|...| .:...||...
 Worm   394 VRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQ----VEEMISLIMESFVDLL-LSEDWLTKET 453

  Fly   352 LAYVRAKLEGIQIKIG-----NLP-----EEKSPEFYNNHYGSANFS-ATNFLANLLEAFALRTR 405
            ....:.|:..::.|||     |.|     |.|:.:.|..||....|| ...:..::||      |
 Worm   454 KQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLE------R 512

  Fly   406 LQNAGLLARNSRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSL- 469
            :..|        ||...:...    .|..:.||....|.|..|...|| |:|..::   |..|:
 Worm   513 ITEA--------VDRERWVAG----AALVNAFYSPNTNEIIFPAGILQ-PVFYSKD---FPSSMN 561

  Fly   470 ---LGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRE-------SKPFRDAIKCAEEQ--PFV- 521
               :|.|:|||:.|.|:..|.|:|..||       ||:       || |....:|.|:|  .:|
 Worm   562 FGGIGVVIGHEITHGFDDRGRLYDNLGN-------IRQWWDNATISK-FEHKAQCIEKQYSSYVL 618

  Fly   522 ----------SLK-ERLADLNGLQLAYDAFFGLAHDSRQFEYR----PYAFEQEFTAPQLFHLSY 571
                      |.| |.:||..||:.||.|:       :::|.|    |.......|..|||.|:|
 Worm   619 DQINMQINGKSTKGENIADNGGLKQAYRAY-------KKYEKRHSRPPRLPGVNLTHDQLFFLNY 676

  Fly   572 AQFFCGSLPPVIA--------HDRDDERVNVSVGNLRQFAYDFNCE----TSPSSVCEMW 619
            ||.:||::....|        |.....||...:.|...||..:|||    .:|...|.:|
 Worm   677 AQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	155/717 (22%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	159/731 (22%)