Protein Alignment Nepl10 and nep-18

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 713
• Identity: 150/713 - (21%)
• Similarity: 255/713 - (35%)
• Gaps: 175/713 - (24%)

  Fly    32 IHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFERVEDQFATAMVEFMESHLGENDTLAPRLIK- 95
            |.|..|.:..||.:|:...|||:|         |.|.|..:...|::.:. |.:...:|.:..|
 Worm    39 IKNYQNASVDPCEDFFEHTCGRYS---------EHVMDDNSWGYVQYKQL-LYQVFAIARKTNKF 93

  Fly    96 ------QMRQYYKAC--------------KEDTRKLHGNPRPEELVNQWILHPK----------- 129
                  |:|.:.|:|              :.|..:..|.|         ::.|.
 Worm    94 NSKPNEQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFP---------MIDPNWNEEKFDLSDM 149

  Fly   130 --KFLVYGLNG---VFIDERVDVAANDSM-------------RWVIQLRMPDPADRYSDRRVLQL 176
              |:|....|.   :.::....:..|.|:             .|.:.:.:...:..:..||:|:|
 Worm   150 LAKYLSINRNRMGFLSVEPYAAIEGNKSVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKL 214

  Fly   177 -MRLYEEAWYSMGVVKLVEKMHQLQDKYR--AEYP--VVYTWSFSELRQEIP----IPHSFFIEL 232
             .|...|..|.....:||    ||:..:.  |:|.  .:...:.|:.|....    ||...:|::
 Worm   215 ENRELNETIYDKEFAELV----QLEANFSTLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKI 275

  Fly   233 L------GVNHTEE---LYHLTFEVSDVEYLRECFRCLRDFASEPKD---TYIRARQYVLV---- 281
            |      |.:..:|   |..:|...:...:..|.....|.....||.   .|:..||.:.|
 Worm   276 LKALARHGTSEEDEEKLLERVTVHGAGEYFFGENRELARIATETPKSALANYLVVRQLIDVALYF 340

  Fly   282 -EESEPRER-------NPRSCIHHMRAYLPL-GMNYIYDRFIYQNREEDTSKVLEILSTLKAAFG 337
             ::.:||:.       ....|...:.::.|: .||...:.  .|.:.|:...:.|:...:||.:.
 Worm   341 YDKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIES--SQFKIENLKVIEEMFVKIKAEYE 403

  Fly   338 QYLDANR-LQLTPNQLAYVRAKLEGIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFA 401
            |....|. |:|...:  ::..||..|..|.|.....:........|.:.||..|:
 Worm   404 QIFTENEYLELEIRE--FLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTD---------- 456

  Fly   402 LRTRLQNAGLLARNSRVDLRHYYVND------NVRKARTSPFYENERNTITVPMEFLQWPLFDHR 460
              :..|....:.|:....|..:.|:|      |::...|...|:...|...:.:.:|.:|..|..
 Worm   457 --SPWQVYMKMWRHWSEQLVEHIVHDTPLDPVNLKMFGTHAAYQPYPNHFYINLPYLTYPWMDAD 519

  Fly   461 EHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAG----------NESPVGLEIRESKPFRDAIKCA 515
            ......:..||.|:|||:.|||:......|.:|          |.|....|:||        ||.
 Worm   520 FPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELRE--------KCL 576

  Fly   516 EEQPFVSLKERLAD--LNGLQLAYDA---FFGLAHDSRQFEYRPYAFEQEFTAP-------QLFH 568
            .:| :.:.||...|  :||....|:.   ..|:....|.||  ....|..|..|       |||.
 Worm   577 RDQ-YSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFE--KVKKEDRFRLPGLEMSEEQLFF 638

  Fly   569 LSYAQFFCGSLPP------VIA--HDRDDERVNVSVGNLRQFAYDFNC----ETSPSSVCEMW 619
            .:||...|....|      ::|  |..:..|||..:.|:.:||..|||    ..:|...|:::
 Worm   639 YNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	143/687 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	146/701 (21%)