Protein Alignment Nepl10 and nep-22

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 791
• Identity: 143/791 - (18%)
• Similarity: 254/791 - (32%)
• Gaps: 267/791 - (33%)

  Fly    29 SNDIHNNLNRTTSPCTNFWNFACGRF-----------SSASKYVDNFERVEDQFATAMVEFMESH 82
            :|.:.|.|:.|..||.:|:.|.|.:|           |....|......|..:...|:     |.
 Worm    72 ANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAAL-----SK 131

  Fly    83 LGENDTLAPRLIKQMRQYYKACK---------------EDTRKLHGNP---RP-EELVNQWIL-- 126
            :....|...:..:..:..::.||               |.|....|.|   .| :..|:.|::
 Worm   132 IDVTSTTTSKTERITKAAFETCKNNLASPADKTAVVYAEITSLFGGVPFFGEPLKTNVDYWMVAG 196

  Fly   127 ----------------------HPKKFLVYGLNGVF--------------IDERV-DV------- 147
                                  |.|..|..|..|:.              :::|| ||
 Worm   197 QIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFYVKPQYIAEVNQRVSDVNDLLTAF 261

  Fly   148 ---------------AANDSMRWVIQLRM---PDPADRYSDRRVLQLMRLYEEAWYSMGVVK--- 191
                           ||.:.:.:.:|:.|   ||           .|:|.|::.:....:..
 Worm   262 ANAAKKNVGADALLAAAQEVVNFEVQIAMASWPD-----------DLLRNYQQQYNPYNIASATT 315

  Fly   192 ----------LVEKMHQL-QDKYRAEYPVVYT------W---SFSELRQEIPIPHSFFIELLGVN 236
                      |.:..|.: .|..:|.|.:|.|      |   .|........:..::.|..|..:
 Worm   316 AYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIAQLLAD 380

  Fly   237 HTEELYHLTFEV-SDVEYLRECFRCLRDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRA 300
            .::.:...|.:| ||..|:....|..|....      |..|:|.:.:.....|    .|:..:.|
 Worm   381 ESDFINPATAKVSSDTNYIHYALRNGRGIKK------IGKREYRMADLDGISE----GCMDLLTA 435

  Fly   301 YLPLGMNYIYDRF------IYQNREEDTSKVLE----ILSTLKAAFGQYLDA---NRLQLTPNQL 352
            |:|.|..|:|.:.      :..:.::.|:.::.    ::.:|     .::|.   ||.....:.|
 Worm   436 YMPYGTGYVYVKSKSERNKVQADVKDQTTLIINNFQGMIDSL-----NWMDTFSKNRAHNKSDSL 495

  Fly   353 AYVRAKLEGIQIKIGNLPEEKSPEF--------YNNHYGSANFSATNFLANLLEAFALRTRLQNA 409
                       :|....||....:|        ||..|.|.....|....::...||:..:
 Worm   496 -----------VKNFGWPEAMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAVLKK---- 545

  Fly   410 GLLARNSRVDLRHYY---------VNDNVRKARTSPFYENERNTITVPMEFLQW--PLFDHREHT 463
                   .:::|.::         .|.....|..:.:|:.|||:||.|  :..|  |.::.....
 Worm   546 -------GMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITFP--YAAWNPPYYNLNYPQ 601

  Fly   464 IFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVG------LEIRESKPFRDAIKCAEEQ---- 518
            .:..:..|...|||:.|.::.||:.|...|..:...      ::...|..|.|..:|...|
 Worm   602 AYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQ 666

  Fly   519 -------------PFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFE------------ 558
                         ...:..|.:|||.|.|.||.:            ||.|...
 Worm   667 CCPEKTGNIHCANGATTQGENIADLGGQQAAYRS------------YRQYVATTRKGVEEDRLPG 719

  Fly   559 -QEFTAPQLFHLSYAQFFC-----GSLPPVI---AHDRDDERVNVSVGNLRQFAYDFNC------ 608
             :.:|..|:|.::|...:|     .:|...:   .|.....|.|..:.::.:|..||.|
 Worm   720 LENYTPNQIFWITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPM 784

  Fly   609 ETSPSSVCEMW 619
            ...||..|::|
 Worm   785 YPEPSGRCKVW 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	134/760 (18%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	137/776 (18%)