Protein Alignment Nepl10 and nep-21

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 784
• Identity: 154/784 - (19%)
• Similarity: 276/784 - (35%)
• Gaps: 209/784 - (26%)

  Fly     5 LLLCSCLVALFI---------------PIQAI--------VDINVATSNDI-------------- 32
            ||:.:.|..||:               ||..:        ||.:....||:
 Worm   121 LLITALLSVLFLWLWVLDGYKTFTDGRPIYPLPFENSSVAVDRSAKNHNDVVCTSRECVRLAGFL 185

  Fly    33 HNNLNRTTSPCTNFWNFACGRFSSASKYVDN------FERVEDQFATAMVEFMESHLGENDTLAP 91
            ..|||...:||.:|:.||||.:........|      ...|:.:....:...::|.:..|:....
 Worm   186 AENLNSKINPCEDFYEFACGNYGLNKNLPANKPLRHTISDVQSRLNKQVKSMLQSPISANEKPWD 250

  Fly    92 RLIKQMRQYYKACKED--------------TRKLHGNPRPE-----ELVNQW------ILHPKKF 131
            ::.|   .||:.|.::              .:::.|.|..|     |..:.|      :|:
 Worm   251 KVAK---GYYQKCLDEEELESTGVEAMRDIAKRIGGWPTLEGDKWQEWSHSWEEQIALVLN---- 308

  Fly   132 LVYGLNGVFIDERVDVAANDSMRWVIQLRMP--DPADRY------SDRRVLQLMRLYEEAWYSMG 188
             :.|:|.|.::..|....::|.|.||:|..|  ....||      :|..:.....|.:....::|
 Worm   309 -LTGVNAVILEMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPMLRNYTTLMKMTAVALG 372

  Fly   189 V-VKLVEKMHQLQDKYRAEYPVVYTWSFS-------------------ELRQEIPIPH------S 227
            . ..:.||  ::.:....|..:|   :||                   :|:...|..:      :
 Worm   373 ADPAIAEK--EMNEAMEFELKLV---NFSADDMVRRDPERGNNRFELWQLKSVFPFINFEKYLKT 432

  Fly   228 FFIEL--LGVNHTEELYHLTFEVSDVEYLRECFRCLRDFASEPKDTYIRARQYVLVEES------ 284
            .|.||  |..||       |..|.:::|.......|:   |.||........:.||:..
 Worm   433 VFKELVALSPNH-------TVIVREIDYFVGIQHVLQ---STPKRVLANYISWRLVQGGPTGDYF 487

  Fly   285 ------EPRERNP--------------------RSCI--HHMRAYLPLGMNYIYDRFIYQNREED 321
                  .|..|.|                    ..|:  ..:...:|:|..::.:.|   .:|..
 Worm   488 SFSPFLPPSAREPFYQFKANQTGMFNSPPPDRWEDCVTLSVIMMDMPVGRLFVENFF---EKERA 549

  Fly   322 TSKVLEILSTLKAAFGQYLDANRLQLTPNQLAYVRAKLEGIQIKIGNLPEEKS---PEFYNNHYG 383
            ..|:.|:.|.||..|.:.|......   :::...||      |...|:.|.||   ...:|:.:.
 Worm   550 MKKMTELTSYLKNEFIKQLHVLDWM---DEITRRRA------ISKANMIEYKSGFPMVLFNDTWM 605

  Fly   384 SANFSATNFLANLLEAFALRTRLQ--NAGLLARNSRVDLRHYYVNDNVRKARTSPFYENERNTIT 446
            ..|:.........|....:|.:|.  ...||..:..:|...::.:    .|:...:|....|.:.
 Worm   606 EKNWGMIIKPREYLLHLTIRVKLVRFTEELLRLDQPLDRSMWFQS----PAQVDAYYAPNNNEMI 666

  Fly   447 VPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDA 511
            .|...:|:|...........:.::|||:|||::|||:.:|..:|..||.:. ..:....:.|.:.
 Worm   667 FPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLND-WWDAETEEKFIEK 730

  Fly   512 IKCAEEQ--------------PFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFT 562
            .:|...|              ..:||.|.:||..|::.|::|:.....::...........|.||
 Worm   731 TRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFT 795

  Fly   563 APQLFHLSYAQFFCGSLPP-----VI---AHDRDDERVNVSVGNLRQFAYDFNC----ETSPSSV 615
            :.|:|.|:||..:|..:.|     :|   .|.....|..:.:.|..:||..|.|    ..:|...
 Worm   796 SQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERK 860

  Fly   616 CEMW 619
            |::|
 Worm   861 CQVW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	136/694 (20%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	138/708 (19%)