Protein Alignment Nepl10 and nep-16

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001023203.2
• Gene: nep-16 / 177541
• WormBaseID: WBGene00018472
• Length: 868
• Species: Caenorhabditis elegans
• Alignment Length: 704
• Identity: 133/704 - (18%)
• Similarity: 244/704 - (34%)
• Gaps: 199/704 - (28%)

  Fly    22 VDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSS--ASKYVDNFERVEDQFATAMVEFMESHLG 84
            :||....|:.|.:.:    .||.||:.::|.|:.|  |.|.:....:::|:....|...:.|.
 Worm   240 IDIAFRLSSCIDDEI----EPCENFYRYSCQRYHSQTADKQMSFLSQLKDESLRRMHSLLSSE-- 298

  Fly    85 ENDTLAPRLIKQMRQYYKACKEDTRKLHGNPRPEELVN----------------------QWILH 127
            |:..|.|:..:..|..|.||....  |..:..|.:|:.                      .|..|
 Worm   299 EDSRLLPKSARLSRSLYSACMNAV--LRSSNAPTDLLTFIRNFPCGPLLRDCQNFHADSYSWERH 361

  Fly   128 PKKFLVY-GLNGVFIDERVDVAANDSMRWVIQLRMPD--PADRYSDRRVLQLMR----------- 178
            ......| |...:.:.:| ||...|..:.::|::.||  |.....:|.::.|.|
 Worm   362 AGMLDWYAGRYNLIVYDR-DVHPQDRSKIILQIKPPDLTPIVGLIERDLIDLARPSPTEFEPLLQ 425

  Fly   179 ------------------------------------LYEEAWYS---------MGVVKLVEKMHQ 198
                                                ||..|..|         |.:.::.:.:.|
 Worm   426 LSLRQNLLSAFARDSLLRDPRDVQSQLDEVARLMVDLYISARQSASLTPNTTYMTIGEMFQALPQ 490

  Fly   199 --LQDKYRAEYPVVYTWSFSELRQEIPI-PHSFFIELLGV-----NHTEELYHLTFEVSDVEYLR 255
              |::...|:....|.|:.:::   :.| .:.:|..|..:     ......|.||..|.:
 Worm   491 LYLREFLDAQLSNTYRWTETDM---LSIQDYDYFARLSDIMAQTSRQAVANYLLTVTVWN----- 547

  Fly   256 ECFRCLRDFASEPKDTYIRARQYVLVEESEPRERNPRSCIHHMRAYLPLGMNYIYDRFIYQNREE 320
                 |:.::..|:|.|                 ..|.|:..:.:: .:|.....|:   .::..
 Worm   548 -----LKQYSYSPRDQY-----------------GWRECVDQISSF-EIGRKMYVDK---ASQTI 586

  Fly   321 DTSKVLEILSTLKAAFGQYLDANRLQLTPNQLAYVRAKLEGIQIKIGNLPEEKSPEFYNNHYGSA 385
            |..|:.|.|..||..|   |..:|  .||  |.|: :.:..:...:|.....::.|.........
 Worm   587 DLPKIQEFLQNLKIDF---LSVHR--STP--LQYL-SNINRLGFYVGFPRRLQNEELIWKPVSQV 643

  Fly   386 NFSATNFLANLLEAFALRTRLQNAGLLARN-SRVDLRHYYVNDNVRKARTSP------FYENERN 443
            :.:.|::..:::          ..|...|: :...:..|..||:   ..|.|      .|.:...
 Worm   644 SLNETDYFDSMI----------RVGKAERDYTMSQIGTYLDNDD---TTTFPISDPTMLYNSNVG 695

  Fly   444 TITVPMEFLQWPLFDHREHTIFQ--HSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRES- 505
            .|.:|:.|::.|::...:.....  :|.||......::..|.|        |.:....||..::
 Worm   696 AIVIPLAFIEPPIYLPGDEVPMYGIYSSLGITTLQMISKVFWQ--------GLDKTSQLECLDNV 752

  Fly   506 -KPFRDAIKCAEEQPFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAP----- 564
             :.|.||.:  :..|.:. .|.||.   ::|| |||....:...::: ..:....|.|.|
 Worm   753 FRGFLDANR--QRSPNIE-PELLAT---IELA-DAFKSALYSYAKWQ-NDHHIHHEKTLPAFDST 809

  Fly   565 ---QLFHLSYAQFFC---GSLPPVIAHDRDDE-RVNVSVGNLRQFAYDFNCETS 611
               :...|:::..||   ||.|     ..|.| .:|....|.|.|:..|||..|
 Worm   810 DSMRSLMLTFSTMFCSGEGSEP-----GSDYEAMINTVAENSRMFSIHFNCNNS 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	126/680 (19%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:472708	91/534 (17%)