Protein Alignment Nepl10 and nep-17

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001254395.1
• Gene: nep-17 / 174996
• WormBaseID: WBGene00010070
• Length: 1589
• Species: Caenorhabditis elegans
• Alignment Length: 781
• Identity: 146/781 - (18%)
• Similarity: 265/781 - (33%)
• Gaps: 221/781 - (28%)

  Fly    16 IPIQAIVDINVATSN------DIH-NNLNRTTSPCTNFWNFACGRFSSASKYVDNFERVEDQFAT 73
            :|...|...||...|      |.: .::|....||.:|:::|||.|:.:.    :|.....|...
 Worm   853 VPEAPITSTNVDKMNAYQMAVDYYAKSVNTAIDPCDDFYSYACGNFNQSV----SFYTARAQNLV 913

  Fly    74 AMVEFMESHLGENDTLAPRLIKQMRQYYKAC-----------------------KEDTRKLHGN- 114
            .|.:.:|....:....:...:|:.:|.|.||                       .:|.:.|.|.
 Worm   914 YMAQKLEDPTYQTTINSSPALKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTLIGQD 978

  Fly   115 -----------PRPEELVN---------------------QWILHPKKFLVYGLNGVFIDERVDV 147
                       |..:::.:                     .||.:.|.:      .:|||:....
 Worm   979 FTLVNGGAPKLPSAKQIGDALGYLSFEQGIDTLISPLVDTYWIDNSKGY------QMFIDQNTAY 1037

  Fly   148 AAN---DSMRWVIQ----LRMP-DPADRYSDRRVLQL---------------------------- 176
            .:.   ....|.|:    |:|. |...||:..:.:.|
 Worm  1038 LSKTYYQPAAWKIEKPKYLKMALDVVTRYAREQNITLPAGASDLLSNVLDYEQNIAVKYSTDDNT 1102

  Fly   177 MRLYEEAWYSMGVVKLVEKMHQLQD--KYRAEYPVVYTWSFSELRQEIPIPHSFFIELLGVNH-- 237
            .|.::.:|.......||.| :...|  .|.:..|.......::...::.:     :|:..:.|
 Worm  1103 RRQFQRSWNLTKTSDLVTK-YNFMDWMTYLSHAPNAVKAKITDANYQVSV-----MEVDRLTHFS 1161

  Fly   238 -------TEELYHLTFE---VSDVEYLRECFRCLRDFASEPKDTYIRARQYVLVEESEPR---ER 289
                   .|.|.:|.|.   :.:.:|:.......|....|.....:..|:.:......|.   |.
 Worm  1162 ADYLQQSPELLVNLLFVRLLLGNAQYIPSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEA 1226

  Fly   290 NPRSCIHHMRAYLPLGMNYIYDRFIYQNREEDTS-------KVLEILSTLKAAFGQYLDANRLQL 347
            |..:|.......:......::..::|...::.|:       .:..::|:.:....| ||    .:
 Worm  1227 NGPACASVANNLMQFANGRVFVDYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQ-LD----WM 1286

  Fly   348 TPN--QLAYVRAKLEGIQIKIGNLPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAG 410
            .|:  |.||  ||...||..|.      .|::..|.....|:.:|..:|:....:.:..:|....
 Worm  1287 APDTKQKAY--AKTVQIQQNIA------FPDWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFN 1343

  Fly   411 LLARNSRVDLRHYYVNDNVRKART-SPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVL 474
            :..:.::::.......|.:.:..| :.:|:.|.|:||.|...|..|.|:........:..:|.|.
 Worm  1344 IFVQYNQLNAAQTDRTDFLGQPGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVA 1408

  Fly   475 GHEMNHAFEQEGILFDAAGN-------ESPVGLEIRESKPFRDAIKCA--EEQPFVSLK------ 524
            |||:.|.|:.:|:.:...||       .|..|        |::..:|.  |...|..|.
 Worm  1409 GHELTHGFDDQGVQWGPTGNLARWMDDNSMAG--------FKNMSQCVINEYSGFCPLNATNYSP 1465

  Fly   525 ----------ERLADLNGLQLAYDAFFGLAHDS----------RQFEYRPYAFEQEFTAPQLFHL 569
                      |.:||..|:..|::|:  ..|.|          |.|        .:||..|||.:
 Worm  1466 NCVKGPQTQGENIADNGGVHAAFNAY--KTHQSLDGPDPRLPDRLF--------GQFTHDQLFFM 1520

  Fly   570 SYAQFFCG---------SLPPVIAHDRDDERVNVSVGNLRQFAYDFNC----ETSPSSVCEMWRP 621
            |:||.:|.         :...|..|.....||..::.|...|...|||    :::|...||:|.|
 Worm  1521 SFAQVWCEVRRTDDALYTQIMVDPHSPSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVWVP 1585

  Fly   622 G 622
            |
 Worm  1586 G 1586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	131/729 (18%)
nep-17	NP_001254395.1	M13	112..831	CDD:341056
		M13	884..1581	CDD:341056	134/743 (18%)