Protein Alignment Nepl10 and nep-1

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 771
• Identity: 171/771 - (22%)
• Similarity: 284/771 - (36%)
• Gaps: 190/771 - (24%)

  Fly     5 LLLCSCLVALFIPIQAIVDIN--VATSND-----------------------------IHNNLNR 38
            |:||..:.||........|||  ..||.|                             :..:||.
 Worm    18 LILCGTVDALPRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGDSEGYQEASRLLQKSLNL 82

  Fly    39 TTSPCTNFWNFACGRFSSASKYVDNFERVEDQFATAMVEFMESH-LGENDTLAP--RLIKQMRQY 100
            :..||.:|:.:||..:..:....|:........||......|.. |.|::|..|  :.|..::|.
 Worm    83 SLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVLAEMRKLYEDNTSIPTSKSIALIKQI 147

  Fly   101 YKACKEDTRKLHGNPRPEELVNQ------W-ILHPKKF------LVYGLNGVFIDERVDV----- 147
            |..|. ||.| |......:|:.:      | ::|.:|:      |...|:.......|.|
 Worm   148 YNTCM-DTEK-HNAVGARDLLEKIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSRDVSVFFDFG 210

  Fly   148 AANDSMRWVIQLRMPDPA---------DRYSD-RRVLQLMRLYEEAWYSMGVVKL---------- 192
            .|.||.....:|...|..         |.|.| ::..:.|:.|.:  |::|.|:.
 Worm   211 PAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKYEKQMKAYRK--YTIGKVRYYTEDAGMAVN 273

  Fly   193 -------VEKMHQLQDKY---------RAEYPVVY-TWSFSELRQEIPIPHSFFIELLGVNHTEE 240
                   |:::...:.::         |..|..:| ...|.:|::.:.|   ...:.|.::.|..
 Worm   274 ESKIESDVDEIIAFEKEWAQILVAEEDRRNYTKLYNVRRFDDLKEYMSI---IDWKKLTLSTTPF 335

  Fly   241 LYHLTFE------VSDVEYLRECFRCLRDFASEPK--DTYIRAR-----------------QYVL 280
            |.|...:      :||||||::....|::  ::|:  ..||..|                 |...
 Worm   336 LVHSYLKTNPSIIISDVEYLQKMNTLLQN--TDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFA 398

  Fly   281 VEESEPRERNPR--SCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDAN 343
            .:....::|.||  .|:......|......:|.|..:....::|:  |::::.|:.||...:.||
 Worm   399 FQMYGRKQRQPRWKDCVSSAGGKLSYASGSMYVRKYFDANAKNTT--LDMITDLQEAFRNMMHAN 461

  Fly   344 RLQLTPNQLAYVRAKLEGIQIKIGN----LPEEKSPEFYNNHYGSANFSATNFLANLLE---AFA 401
            . .:......|...|.:.:..:||.    |.:||..::|....|:...|.:..:...::   .|.
 Worm   462 D-WMDAETKKYALEKADQMLKQIGYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFY 525

  Fly   402 LRTRLQNAGLLARNSRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQ 466
            .|..|:...          |..:::.   .|..:.||...||.|..|...||.|.||.|......
 Worm   526 YRRLLEPVN----------RFEFISS---AAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALN 577

  Fly   467 HSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRE------SKPFRDAIKCAEEQPFVSLK- 524
            :..:|||:|||:.|.|:..|..||..||       :|:      |..|.:..:|..|| :..:|
 Worm   578 YGGIGAVIGHEITHGFDDTGRQFDNVGN-------LRDWWDNTTSSKFNERTQCIIEQ-YADVKL 634

  Fly   525 --------------ERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFF 575
                          |.:||..|::.|:.|:..........|.|...|| ..|..|||.:.|||.:
 Worm   635 RGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFE-SLTNEQLFFVGYAQVW 698

  Fly   576 CGSLPP--------VIAHDRDDERVNVSVGNLRQFAYDFNCET----SPSSVCEMW 619
            ||:..|        ...|..:..|||..:.|..:||..|.|..    :|:..|.:|
 Worm   699 CGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	154/687 (22%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	156/699 (22%)