Protein Alignment Nepl10 and Eef1ece2

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_808810.1
• Gene: Eef1ece2 / 110599584
• MGIID: 6121518
• Length: 910
• Species: Mus musculus
• Alignment Length: 746
• Identity: 168/746 - (22%)
• Similarity: 278/746 - (37%)
• Gaps: 187/746 - (25%)

  Fly     6 LLCSCLVALFI---PIQA--IVDINVATSNDIHNNLNRTTSPCTNFWNFACGRF-------SSAS 58
            ||..|||||::   |..:  :.:..:..:..|..:|:|..|||.:|:.|:||.:       :..|
Mouse   220 LLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRS 284

  Fly    59 KYVDNFERVEDQFATAMVEFMESHLGENDTL--APRLIKQMRQYYKACKEDTR--KLHGNPRPE- 118
            :: :.|..:.||....:     .||.||.|.  :....::.|.:|.:|.:..|  ||...|..:
Mouse   285 RW-NTFNSLWDQNQAIL-----KHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDL 343

  Fly   119 -ELVNQW-ILHP--------------------KKFLVYGLNGVFIDERVDVAANDSMRWVIQ--L 159
             :.:..| |..|                    ..|.||    |..|.:   ::|.::..|.|  |
Mouse   344 IDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVY----VSADSK---SSNSNIIQVDQSGL 401

  Fly   160 RMPDPADRYSDRRVLQ-LMRLYEEAWYSMGVV------KLVEKMHQL-------------QDKYR 204
            .:|. .|.|.:|...: ::..|.:....:||:      ...|:|.|:             ||:.|
Mouse   402 FLPS-RDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRR 465

  Fly   205 AEYPVVYTWSFSELRQEIPIPH-----SFFIELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDF 264
            .|..:.:..|.|||:...|...     ||.:..|.:..:|.:.     |...|||::....:.
Mouse   466 DEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVV-----VYGTEYLQQVSELIN-- 523

  Fly   265 ASEPK------------------DTYIRARQYVLVEE--SEPRERNPR--SCIHHMRAYL--PLG 305
            .:||.                  |......|..|:|.  ...:...||  :||.:....|  .||
Mouse   524 RTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALG 588

  Fly   306 MNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQ--YLDANRLQLTPNQLAYVRAKLEGIQIKIGN 368
            ..::...|..|::|.....:.||.|..:...|.  ::|..      .:|| .:.|.:.|...||.
Mouse   589 SLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDEK------TRLA-AKEKADAIYDMIGF 646

  Fly   369 LPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVNDNVRK-- 431
            ......|:..::.|.....|..:|..|:|..:....::                  :.|.:||
Mouse   647 PDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKV------------------MADQLRKPP 693

  Fly   432 ---------ARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGI 487
                     ...:.:|...:|.|..|...||.|.:.|..........:|.|:|||:.|||:.:|.
Mouse   694 SRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGR 758

  Fly   488 LFDAAGNESPVGLEIRESKPFRDAIKCAEEQ------------PFVSLKERLADLNGLQLAYDAF 540
            .:|..||..| ..:......|::...|.|||            ...:|.|.:||..||:.||:|:
Mouse   759 EYDKEGNLRP-WWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAY 822

  Fly   541 FGLAHDSRQFEYRPYAFEQE-----FTAPQLFHLSYAQFFCGSLPPVIAHD---RDDE-----RV 592
                    :...|.:..||.     .|..|||.:.:||.:|....|..:|:   .|..     ||
Mouse   823 --------KAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRV 879

  Fly   593 NVSVGNLRQFAYDFNCET----SPSSVCEMW 619
            ..::.|.|.|...|.|..    :|..:||:|
Mouse   880 LGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	152/689 (22%)
Eef1ece2	NP_808810.1	UbiG	46..>128	CDD:441829
		M13	259..908	CDD:341056	154/703 (22%)