Protein Alignment Nepl10 and Ece2

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 746
• Identity: 168/746 - (22%)
• Similarity: 278/746 - (37%)
• Gaps: 187/746 - (25%)

  Fly     6 LLCSCLVALFI---PIQA--IVDINVATSNDIHNNLNRTTSPCTNFWNFACGRF-------SSAS 58
            ||..|||||::   |..:  :.:..:..:..|..:|:|..|||.:|:.|:||.:       :..|
Mouse    73 LLLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRS 137

  Fly    59 KYVDNFERVEDQFATAMVEFMESHLGENDTL--APRLIKQMRQYYKACKEDTR--KLHGNPRPE- 118
            :: :.|..:.||....:     .||.||.|.  :....::.|.:|.:|.:..|  ||...|..:
Mouse   138 RW-NTFNSLWDQNQAIL-----KHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDL 196

  Fly   119 -ELVNQW-ILHP--------------------KKFLVYGLNGVFIDERVDVAANDSMRWVIQ--L 159
             :.:..| |..|                    ..|.||    |..|.:   ::|.::..|.|  |
Mouse   197 IDKIGGWNITGPWDEDSFMDVLKAVAGTYRATPFFTVY----VSADSK---SSNSNIIQVDQSGL 254

  Fly   160 RMPDPADRYSDRRVLQ-LMRLYEEAWYSMGVV------KLVEKMHQL-------------QDKYR 204
            .:|. .|.|.:|...: ::..|.:....:||:      ...|:|.|:             ||:.|
Mouse   255 FLPS-RDYYLNRTANEKVLTAYLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRR 318

  Fly   205 AEYPVVYTWSFSELRQEIPIPH-----SFFIELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDF 264
            .|..:.:..|.|||:...|...     ||.:..|.:..:|.:.     |...|||::....:.
Mouse   319 DEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVV-----VYGTEYLQQVSELIN-- 376

  Fly   265 ASEPK------------------DTYIRARQYVLVEE--SEPRERNPR--SCIHHMRAYL--PLG 305
            .:||.                  |......|..|:|.  ...:...||  :||.:....|  .||
Mouse   377 RTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALG 441

  Fly   306 MNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQ--YLDANRLQLTPNQLAYVRAKLEGIQIKIGN 368
            ..::...|..|::|.....:.||.|..:...|.  ::|..      .:|| .:.|.:.|...||.
Mouse   442 SLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDEK------TRLA-AKEKADAIYDMIGF 499

  Fly   369 LPEEKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQNAGLLARNSRVDLRHYYVNDNVRK-- 431
            ......|:..::.|.....|..:|..|:|..:....::                  :.|.:||
Mouse   500 PDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKV------------------MADQLRKPP 546

  Fly   432 ---------ARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGI 487
                     ...:.:|...:|.|..|...||.|.:.|..........:|.|:|||:.|||:.:|.
Mouse   547 SRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGR 611

  Fly   488 LFDAAGNESPVGLEIRESKPFRDAIKCAEEQ------------PFVSLKERLADLNGLQLAYDAF 540
            .:|..||..| ..:......|::...|.|||            ...:|.|.:||..||:.||:|:
Mouse   612 EYDKEGNLRP-WWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAY 675

  Fly   541 FGLAHDSRQFEYRPYAFEQE-----FTAPQLFHLSYAQFFCGSLPPVIAHD---RDDE-----RV 592
                    :...|.:..||.     .|..|||.:.:||.:|....|..:|:   .|..     ||
Mouse   676 --------KAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRV 732

  Fly   593 NVSVGNLRQFAYDFNCET----SPSSVCEMW 619
            ..::.|.|.|...|.|..    :|..:||:|
Mouse   733 LGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	152/689 (22%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	154/703 (22%)