Protein Alignment Nepl10 and phex

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_004911718.1
• Gene: phex / 100496470
• XenbaseID: XB-GENE-1012247
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 792
• Identity: 152/792 - (19%)
• Similarity: 281/792 - (35%)
• Gaps: 256/792 - (32%)

  Fly     4 LLLLCSCLVALFIPIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFERV- 67
            |||:...|::.......:....:..:..|.:.:|.:..||.:|:.:|||.:...:...|:....
 Frog    39 LLLVSKGLISFQKDEYCLTPECIEAAASIRSKMNLSVDPCDDFFQYACGGWIEENPIPDDMSNYG 103

  Fly    68 --------EDQFATAMVEFMESHLGENDTLAPRLIKQMRQYYKACKEDTRKLHGNPRP------- 117
                    .|....|::|...|...:::.     |::::.:|.:|..:|:....:.:|
 Frog   104 IYPWLRTNVDLKLKALLEKPISKRRDSEA-----IQKVKTFYISCMNETQIEEDDIKPILKILKQ 163

  Fly   118 --------EELV---NQWILHPKKFL--------VYGLNGVFIDERVDVAAND--SMRWVIQLRM 161
                    |..:   .:|......||        :|. ..||:  ||.||.:|  |..::::|
 Frog   164 PSLRWPVLESNIGSDGKWSERKFSFLQTVADLRRLYS-TSVFL--RVYVAIDDKVSNNFILKL-- 223

  Fly   162 PDPA-------DRYSDRRVLQLMRLYEEAWYSMGVVKLVEKMHQL-----QDKYRAEYPVVYTWS 214
             |.|       :.|.|...  :.:.|.:|        |:|.|..:     .:|.|||..:.....
 Frog   224 -DQASLSLLSHEDYLDNST--IAKKYRDA--------LLEFMVDVAVLLGANKTRAETDMKALIE 277

  Fly   215 FSELRQEIPIPHSFFIELLGVNHTEELYHLTFEVSD----------VEYLRECFRCLRDFASEP- 268
            ......:|.:|..        |.|.|:.:....:|:          :.||:.    :.||...|
 Frog   278 LETKLAQITVPQE--------NRTSEMMYNKMNISELSAMIPQFDWLSYLKN----IIDFNIYPE 330

  Fly   269 -------KDTYIRARQYV-----LVEESEPR------------ERNPR----------------- 292
                   ::..:|..|:.     ::|..|.|            .|.|.
 Frog   331 LKNIDLSENVIVRVPQHFKDLFNIIESEEKRTLANYLIWRLVYSRIPNLSRRFQYRQLEFARILL 395

  Fly   293 ----------SCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVL-EILSTLKAAF-------GQY 339
                      .|::::...:|..:..:   |:..:.:||...:: |::..::.||       ..:
 Frog   396 GTNSLAGRWDRCVNYVENSIPYPVGKL---FVDAHFQEDKKDMMEELVDGIRWAFIDMLEKENDW 457

  Fly   340 LDANRLQLTPNQLAYVRAKLEGIQI--KIGNLPEEKSPEF-YNNHYGSAN-----FSATNFLANL 396
            :||.         ..::||.:.:.:  |:|      .||| :|:.|.:.:     ||.:::..|:
 Frog   458 MDAE---------TKIKAKQKAVTVMAKVG------YPEFLFNDTYLNEDIKMLKFSESDYFGNV 507

  Fly   397 LEAFALRTRLQNAGLLARNSRVDLRHYYVNDNVRKAR--TSP-----FYENERNTITVPMEFLQW 454
            |:.            |...|:.|.  |::..||.|..  |:|     ||....|.|..|...||.
 Frog   508 LQT------------LHFISQSDF--YWLRRNVPKKEWFTNPTTVNAFYSASTNQIRFPAGELQK 558

  Fly   455 PLFDHREH-TIFQHSLLGAVLGHEMNHAFEQEGILFDAAGN-------ESPVGLEIRESKPFRDA 511
            |.|...:: ....:..:|.::|||..|.|:..|..:|..||       ||        .:.|::.
 Frog   559 PFFWGVQYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKEGNLFSWWTSES--------EERFKNK 615

  Fly   512 IKCAEEQ--------------PFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFT 562
            ..|..||              ...:|.|.:||..|::.::.|:.....|.|:       .::|..
 Frog   616 TLCMVEQYNNYYWKQAGLHVKGMKTLSENIADNGGIRESFRAYRKWIEDLRK-------GKEEML 673

  Fly   563 AP-------QLFHLSYAQFFCGSLPPVIAHDR--------DDERVNVSVGNLRQFAYDFNCETSP 612
            .|       |||.:|||...|.|.....|.|:        ...||..::.|..:|...|:|....
 Frog   674 LPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGVHSPPQFRVIGAMSNFEEFHKAFSCPKDS 738

  Fly   613 -----SSVCEMW 619
                 ::.|.:|
 Frog   739 KMNRGANSCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	143/737 (19%)
phex	XP_004911718.1	M13	75..741	CDD:341056	144/745 (19%)