Protein Alignment Nepl10 and mmel1

DIOPT Version :10

• Sequence 1: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 760
• Identity: 165/760 - (21%)
• Similarity: 291/760 - (38%)
• Gaps: 184/760 - (24%)

  Fly     1 MGCLLLLCSCLVALFIPIQAIVDINVATSND-------IHNNLNRTTSPCTNFWNFACGRF---- 54
            :..||.|.:|.|...:.:......::.|:..       |..|::.|..|||:|:.:|||.:
 Frog    49 LSVLLFLMTCAVVALLVLYTSHKESICTTTGCVTAAARIIQNMDPTIEPCTDFYQYACGGWLNKH 113

  Fly    55 ---SSASKYVDNFERVEDQFATAMVEFMESHLGENDTLAPRLIKQMRQYYKACKEDT--RKLHGN 114
               .::|:| ..|:.:.|:....:...:|.. .:.|..|   .|:.:..||:|..::  .:....
 Frog   114 VIPETSSRY-SIFDILRDEMEIILKGLLEMP-DQEDRDA---FKKAKILYKSCMNESLIEQRDSL 173

  Fly   115 PRPEELV-----------------NQWILHPK-KFLVYGLN-----GVFI--DERVDVAANDSMR 154
            |..|.|.                 :.|.|..| ..|.|..|     .:|:  |:|      :|.:
 Frog   174 PLLELLTTVGEWPVASTDWNGTKESNWSLEEKLSLLNYKFNKRVLVDIFVWNDDR------ESSK 232

  Fly   155 WVIQLRMPD---PA-DRYSDRRVLQLMRLYEEAW--YSMGVVKLV--------------EKMHQL 199
            .:|.:..|.   |: |.|.::...|.:|   ||:  :.:.:.::|              |:|.::
 Frog   233 HIIYIDQPSLGMPSRDYYFNKGNYQRIR---EAYLQFMITIARMVREDRNLTRDDSLVQEEMTRV 294

  Fly   200 QD------------KYRAEYPVVYT-WSFSELRQEIPIPH---SFFIE--LLGVN---HTEELYH 243
            .|            :.|.:..::|. .:..|.:|:..:..   :.||:  :..||   ..||
 Frog   295 MDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDFNWTSFIQGVMSSVNIQLQAEE--- 356

  Fly   244 LTFEVSDVEYLRECFRCLRDFASEPKDTYI-----------RARQY-------------VLVEES 284
             ...|....||.:....|.::::.....|:           .:|:|             ..:||:
 Frog   357 -EVVVYGAPYLHQLKNILSNYSASTLQNYVVWRMVIDRVSSLSRRYKDARASYRKALYGTTLEEA 420

  Fly   285 EPRERNPRSCIHHMRAYL--PLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQ- 346
            ..||     |:.::.:.:  .:|..|:.:.|..:::.    .:.::::.::.||.:.||  .||
 Frog   421 RWRE-----CVSYVNSNMENAVGAMYVKETFAGESKR----MISDLINKVREAFIETLD--ELQW 474

  Fly   347 LTPNQLAYVRAKLEGIQIKIGNLPE---EKSPEFYNNHYGSANFSATNFLANLLEAFALRTRLQN 408
            :........|.|...|:.:|| .|:   |...:..:....:.|||...:..|:||       :.|
 Frog   475 MDETSKDKAREKALSIKEQIG-YPDYILEDQNDKLDQETAALNFSEYQYFENILE-------ILN 531

  Fly   409 AGLLARNSRVDLRHYYVNDN--VRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLG 471
            :|  |:.|...||.....|.  :..|....||...||.|..|...||.|.|:..:........:|
 Frog   532 SG--AQKSLKKLREPVDQDAWIIGAAVADAFYSPNRNQIVFPAGILQPPFFNKHQPQALNFGGIG 594

  Fly   472 AVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQ---------------PFV 521
            .|:|||:.|.|:..|..||..||........ .:..|:|..:|...|               ..:
 Frog   595 MVIGHEITHGFDDNGRNFDKDGNMFDWWSNF-SAMHFKDQSRCMVYQYGNYTWELAGGQNVSGII 658

  Fly   522 SLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGSLPPVIA-- 584
            :|.|.:||..|::.||.|:....   .:....|.....:.|..|||.|::||.:|||..|..|
 Frog   659 TLGENIADNGGVRQAYKAYLKWV---ERHGKEPKLPGLDLTYKQLFFLNFAQVWCGSYRPEYARH 720

  Fly   585 ------HDRDDERVNVSVGNLRQFAYDFNCETS----PSSVCEMW 619
                  |.....||..|:.|...||.:|||:..    |...|.:|
 Frog   721 SIKTDVHSPFKYRVMGSLQNFEAFAEEFNCKKGTKMHPVEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	151/696 (22%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	154/710 (22%)