Protein Alignment CG8545 and NOP2

DIOPT Version :10

• Sequence 1: NP_610786.2
• Gene: CG8545 / 36365
• FlyBaseID: FBgn0033741
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: NP_014338.3
• Gene: NOP2 / 855664
• SGDID: S000005005
• Length: 618
• Species: Saccharomyces cerevisiae
• Alignment Length: 726
• Identity: 296/726 - (40%)
• Similarity: 407/726 - (56%)
• Gaps: 143/726 - (19%)

  Fly    44 HRQKQ-------RFVKREQKKVVQKAKLQEKRAKGKLPQPAKRKTAYNSDSDPEDNEEEPQVASS 101
            |:.||       .|..|::||..:|.:      |||.|.                       .:.
Yeast     6 HKNKQAAPPTLEEFQARKEKKANRKLE------KGKRPS-----------------------TTQ 41

  Fly   102 DEEVPQLVPAPKGQKATAPKGFTDDNDAWLKPKKQQKQPETESEEEEEEDEESEEDSEDELGEEC 166
            .:||                     :|...|..|..|:...|.||..|||::..|...:||.:..
Yeast    42 GDEV---------------------SDRKKKKSKPFKKSRKEEEEVVEEDKDLPEVDLEELSKAR 85

  Fly   167 E---EEEEGDDEEGLESDDDTAQVGKLADLSDDDDANSDDDFDISGEEDGAQADSDEEEDEDDD- 227
            :   ::||.|||.||..:          :|.|:.|...:.|:|               ||||:|
Yeast    86 KSLFDDEEDDDEAGLVDE----------ELKDEFDLEQEYDYD---------------EDEDNDA 125

  Fly   228 -----DDDDDDDDDKL---PIERANKKLKKREAEEAQLADDEMLETVDKQ---DVFQLPVEGEE- 280
                 ||||:.|.::|   .:|..:|||.:.|||||:.|:.|::|..:.|   |:  ||.|.:|
Yeast   126 HPIFSDDDDEADLEELNAQNMEALSKKLDEEEAEEAEEAEMELVEAENMQPRADI--LPTEEQEE 188

  Fly   281 --TEKDLTLQEVQQRIKDVSLVLSDFKRYRQADRSRGEYIDLLRRDLCLYYSYNEFLMEKLMDML 343
              .::...|...:.|:.::..||.:||......||||||:|.|.:|:|.|:.|..||.|||.::.
Yeast   189 MMAQETPNLTSTRTRMIEIVKVLENFKTLGAEGRSRGEYVDRLLKDICEYFGYTPFLAEKLFNLF 253

  Fly   344 PLTELMEYLEASEIARPLTIRTNTLKTRRRDLAGALINRGVNLDPLGKWTKVGLVVFNSQVPLGA 408
            ...|.||:.||:|||||:|||||||||||||||..|:||||||.|:|.||||||.:|:||||:||
Yeast   254 SPAEAMEFFEANEIARPITIRTNTLKTRRRDLAQTLVNRGVNLQPIGSWTKVGLQIFDSQVPIGA 318

  Fly   409 TPEYLAGHYMIQGASSLLPVMALAPQENERILDMCSAPGGKGSHIASIMKNTGVLFANDSNRDRI 473
            |||||||||::|.|||.|||:||.|.||||||||.:|||||.::|:::|||||.:||||:|:.|.
Yeast   319 TPEYLAGHYILQAASSFLPVIALDPHENERILDMAAAPGGKTTYISAMMKNTGCVFANDANKSRT 383

  Fly   474 KAIVANFHRLGIVNAVVSCEDGTKFRNIMTGFDRVLLDAPCTGTGVVSKDPSVKTTKSEVDVQRC 538
            |:::||.||||..|.:|...|..:|..::.||||:||||||:||||:.||.|||.:::|.|..:.
Yeast   384 KSLIANIHRLGCTNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQI 448

  Fly   539 YNLQRKLLLTAIDCTDAKSSTGGYIVYSTCSVLPEENEWVIDYALKKR-NVKLVPTGLDFGVEGF 602
            .:||::|||:|||..|..|..||.||||||||..||:|.||||||:|| |||||.|||..|.|.|
Yeast   449 PHLQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRKRPNVKLVDTGLAIGKEAF 513

  Fly   603 TKFRQHRFHPSLNLTKRYYPHTHNMDGFYVAKLKKFSNTIPITKEQQEEDEKQLDEAIEADATTE 667
            |.:|..:||||:.|.:||||||:|:|||:|||.:|..   |.:.:..:...|:          .|
Yeast   514 TSYRGKKFHPSVKLARRYYPHTYNVDGFFVAKFQKIG---PSSFDDNQASAKE----------KE 565

  Fly   668 AAAESEEVEEEVASKEKGPRKLLGKRAGKPSFTEIEQELKKKKREESKTKYVAKVFEQPVKK--- 729
            .||..|.:||.:...:               |...|        :|...||:.|..:..:.|
Yeast   566 TAARKEALEEGIIHSD---------------FATFE--------DEEDDKYIEKSVKNNLLKKGV 607

  Fly   730 -PKPEKPAEKK 739
             ||.::|:.:|
Yeast   608 NPKAKRPSNEK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	nop2p	363..637	CDD:188051	174/274 (64%)
		PRK13808	<745..886	CDD:172341
NOP2	NP_014338.3	nop2p	273..548	CDD:188051	174/274 (64%)