DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8545 and NSUN7

DIOPT Version :9

Sequence 1:	NP_610786.2	Gene:	CG8545 / 36365	FlyBaseID:	FBgn0033741	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_078953.4	Gene:	NSUN7 / 79730	HGNCID:	25857	Length:	718	Species:	Homo sapiens

Alignment Length:	691	Identity:	164/691 - (23%)
Similarity:	257/691 - (37%)	Gaps:	191/691 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 DDDDDDDDKLPIERANKKLKKREAEEAQLAD----------DEMLETV-----DKQD-VFQLPVE 277
            :.:|....:|..|.|...||.::..|..|.|          |.:...:     |.|| .||..|.
Human    80 ESEDQSFQRLSYELAFSALKYQDILETILIDSCIFPSTTIPDHLSSLIIVMLYDFQDRKFQTRVL 144

  Fly   278 GEETEKDLTLQEVQQRIKDVSLVLSDFKRYRQADRSRGEYIDLLRRD-LCLYYSYNEFLMEKLMD 341
            .:..|....:|||:.       :|:.||....|..:|..    ::.| |.:|:
Human   145 SDNEEPISEVQEVEN-------LLNSFKIKLAAALARCR----IKHDALSIYH------------ 186

  Fly   342 MLPLTELMEYLEASEIARPLTIRTNTLKTRRRDLAGALINRGVN-------LDPLGKWTKV---- 395
            :||.|...:.|.||.:  ||....||.|....::...|..||.|       :|     .||
Human   187 ILPETVRKQELRASTL--PLYAWINTCKISPEEVYNNLKRRGYNKVKSVLHID-----DKVFAVD 244

  Fly   396 ----GLVVF-----NSQVPLGATPEYLAGHYMIQGASSLLPVMALAPQEN--ERILDMCSAPGGK 449
                .:::|     |..:.:....:|   ..:.|..|..|.|.::....|  :.:|.:.:.....
Human   245 QHCYDVLIFPSHLKNDLINIDLFKDY---KLIFQDKSRSLAVHSVKALLNMDDDVLMVNTGSWYT 306

  Fly   450 GSHIASIM-KNTGVLF-------ANDSNRDRIKAIVANFHRLGIVNAVVSCEDGTKFRNIMTGFD 506
            .||::.:. .||..:|       |.|.:   :|.:   |.::|..|..:..|   ||.||.:...
Human   307 VSHMSILTNNNTSKVFVCGVQSQAKDPD---LKTL---FTKIGCKNIEILHE---KFINIESKDH 362

  Fly   507 R------VLLDAPCTGTGVVS---------------KDPS---VKTTKSEVDVQRCYNLQRKLLL 547
            |      :||...|:|.||.:               ||.|   :...|..|..|:.|    :.|.
Human   363 RLQKVKVILLLPRCSGLGVSNPVEFILNEHEDTEFLKDHSQGGISVDKLHVLAQQQY----EQLT 423

  Fly   548 TAIDCTDAKSSTGGYIVYSTCSVLPEENEWVIDYALKKRNVKLVPTGLDFGVEGFTKFRQHRFHP 612
            .|:..|.|::     :||.||||.|||||.|:..||:.:         |.|.:|    :.:|..|
Human   424 HAMKFTKAQA-----VVYCTCSVFPEENEAVVKKALEFQ---------DLGNKG----QPYRLSP 470

  Fly   613 ---SLNLTKRYYPHTHNMDGFYVAKLKKFSNTIPITKEQQEEDEKQLDEAIEA-DATTEAAAESE 673
               .|...|.....|   |.|:..:..:.:|...::...:|.|.   .|.:.. |....|||
Human   471 PVLPLCSLKEIQLST---DKFFRMEPSEITNGCFLSILTRERDP---SETVSVNDVLARAAA--- 526

  Fly   674 EVEEEVASKEKGPRKLLGKRAGKPSFTEIEQELKKKKREESKTKYVAKVFEQPVKKPKPEKPAEK 738
                      ||  .|.|...||.|    ::|.||||.:.|.||  ....:..::.    |.||.
Human   527 ----------KG--LLDGIELGKSS----KREKKKKKSKTSLTK--GATTDNGIQM----KIAEF 569

  Fly   739 KNEKSQAPDKQTNSSESPSKSAPKQKQTNGKTTVSNSDAKSFNKKNKGSQPKENGAGSPAKPDDN 803
            .|.:::|   ..|.||:.:|  |...|.|.....::|..:..||.          |..||.|...
Human   570 LNRETKA---SANLSETVTK--PPLPQKNTAQVGASSQTRKPNKL----------APHPAVPAFV 619

  Fly   804 KPTTNGTNSPSKSAIKETK-TKPQPKGKQSPKGNAKLAKAP 843
            |.|     .||:...::|. .:|:|:.:.......|:...|
Human   620 KNT-----CPSRPRERQTHFLRPRPEDRMVALKPIKIVLPP 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	Methyltr_RsmF_N	333..424	CDD:293730	22/110 (20%)
		nop2p	363..637	CDD:188051	77/330 (23%)
		Nol1_Nop2_Fmu	428..636	CDD:279522	61/244 (25%)
NSUN7	NP_078953.4	Methyltr_RsmF_N	131..509	CDD:330305	104/444 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..557		11/26 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..616		13/49 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1128973at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820