DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8545 and NSUN5

DIOPT Version :9

Sequence 1:	NP_610786.2	Gene:	CG8545 / 36365	FlyBaseID:	FBgn0033741	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_001161819.1	Gene:	NSUN5 / 55695	HGNCID:	16385	Length:	470	Species:	Homo sapiens

Alignment Length:	365	Identity:	103/365 - (28%)
Similarity:	158/365 - (43%)	Gaps:	74/365 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 SYNEFLMEKLMDMLPLTELMEYLEASEIARPLTIRTNTLKTRRRDLAGALINRGVN--------- 385
            |.||.|:|......|.::|           |..:|.|||||...|:......:|.:
Human   116 SRNEDLLEVGSRPGPASQL-----------PRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLD 169

  Fly   386 -----------LDPLGKWTKVGLVVFNSQVPLGATPEYLAGHYMIQGASSLLPVMALAPQENERI 439
                       ||||    ...|:||.:|..|...|.|.|||.::|..:|.||.|.|.|.....:
Human   170 DLRALKGKHFLLDPL----MPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHV 230

  Fly   440 LDMCSAPGGKGSHIASIMKNTGVLFANDSNRDRIKAIVANFHRLGIVNAVVSCEDGTKFRNIMTG 504
            :|.|:|||.|.||:|:::||.|.:||.|.:..|:.::.....|.|:....::.||   |..:...
Human   231 IDACAAPGNKTSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEED---FLAVSPS 292

  Fly   505 FDR------VLLDAPCTGTGVVSK---DPSVKTTKSEVDVQRCYNLQRKLLLTAIDCTDAKSSTG 560
            ..|      :|||..|:|:|:.|:   :|.. .|.|.|.:......|::.|..|:.....:.
Human   293 DPRYHEVHYILLDPSCSGSGMPSRQLEEPGA-GTPSPVRLHALAGFQQRALCHALTFPSLQR--- 353

  Fly   561 GYIVYSTCSVLPEENEWVIDYALKKR--NVKLVPTGLDFGVEGFTKFRQHRFHPSLNLTKRYYPH 623
              :||||||:..||||.|:..||::.  ..:|.|....:...|.:.|      |......|..|.
Human   354 --LVYSTCSLCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTF------PGAEHCLRASPE 410

  Fly   624 THNMDGFYVAKLKKF-------------SNTIPITKEQQE 650
            |....||:||.:::.             ::|.|..||::|
Human   411 TTLSSGFFVAVIERVEVPSLTGQSISTRTHTQPSPKEKEE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	Methyltr_RsmF_N	333..424	CDD:293730	29/110 (26%)
		nop2p	363..637	CDD:188051	90/304 (30%)
		Nol1_Nop2_Fmu	428..636	CDD:279522	64/218 (29%)
NSUN5	NP_001161819.1	RsmB	95..425	CDD:223222	98/338 (29%)
		AdoMet_MTases	219..420	CDD:302624	62/215 (29%)
		S-adenosyl-L-methionine binding	234..240		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1128973at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820