Protein Alignment CG8545 and NSUN2

DIOPT Version :10

• Sequence 1: NP_610786.2
• Gene: CG8545 / 36365
• FlyBaseID: FBgn0033741
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: NP_060225.4
• Gene: NSUN2 / 54888
• HGNCID: 25994
• Length: 767
• Species: Homo sapiens
• Alignment Length: 800
• Identity: 164/800 - (20%)
• Similarity: 273/800 - (34%)
• Gaps: 294/800 - (36%)

  Fly   287 LQEVQQRIKDVSLVLSDFKRYRQADRSRGE------YIDLLRRDLCLYYSYNEFLMEKLMDMLPL 345
            ||: |||.:|.       :...:....|||      |.::::.:....:.|.|      :.::|.
Human    10 LQQ-QQRPEDA-------EDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQE------LKIVPE 60

  Fly   346 TELMEYLEASEIARPLTIRTNTLKTRRRDLAGALINRGV----NLDPLGKWTKVGLVVFNSQVPL 406
            .|..::::|.....|.|:|....|:..:::...|.|:..    :|:..|:..:|       ..||
Human    61 GEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEV-------PQPL 118

  Fly   407 GATPEYLAGH-------------------YMI----------QGASSLLPVMALAPQENERILDM 442
            ...||.||.|                   :::          |.|.|::|.:.|..:.:.:||||
Human   119 SWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDM 183

  Fly   443 CSAPGGKGSHIASIMK-------NTGVLFANDSNRDRIKAIVANFHRLG-----IVNAVVSC--- 492
            |:|||.|.:.:..::.       ..|.:.|||.:..|...:|....||.     :||...|.
Human   184 CAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPR 248

  Fly   493 ----EDGTKFRNIMTGFDRVLLDAPCTGTGVVSKDPSVKTTKSEVDVQRCYNLQRKLLLTAIDCT 553
                .||   |..:..:||:|.|.||:|.|.:.|:..|....:.::..:.:.||.::.....:
Human   249 LQIDVDG---RKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAE-- 308

  Fly   554 DAKSSTGGYIVYSTCSVLPEENEWVIDYALKKRNVKL--------VPTGLDFGVEGFTKFR---- 606
              :.:.||.:||||||:.|.|:|.||...|:|....|        :| ||.: :.|.|:::
Human   309 --QLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELP-GLKW-MPGITQWKVMTK 369

  Fly   607 -----------QHRFHPSLNLTK------------------RYYPHTHNMDGFYVAKLKKFSNTI 642
                       .|..|..:..|.                  |..||..|..||:||.|.| .:::
Human   370 DGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVK-KSSM 433

  Fly   643 PITKEQ-----QEEDEKQLDEAIEADAT--------------------TEAAAESEEVEEEVASK 682
            |..|.|     :..:.::..:...||.|                    ||.|..:|::|...:.|
Human   434 PWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKK 498

  Fly   683 EK--GP-----RKLLGKR---------------------AGKPSFTE---IEQELKKKKRE---- 712
            :.  ||     .||.|.:                     |..|||..   :.:..:.|||:
Human   499 DGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMV 563

  Fly   713 -----------ESKTKYV-----------------------------------AKVFEQPVKKPK 731
                       ..|.|.:                                   :::....::..|
Human   564 SKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVK 628

  Fly   732 ----PEKPAEKK---NEKSQAPDKQTNS---SESPSKSAPKQKQT-------NGKTTVSNSDAKS 779
                .|.|..:|   ...|||.|....|   ...|..:.|...|.       .||.::     ::
Human   629 ILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASI-----RT 688

  Fly   780 FNKKNK-------------GSQPKE------NGAGSPAKPDD-----------NKPTTNGTNSPS 814
            |..||:             |.:.||      ..|.|..:||:           |.|.....|||.
Human   689 FVPKNERLHYLRMMGLEVLGEKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANSPD 753

  Fly   815 KSAIKETKTKPQPKGKQSPK 834
            .:|      ...|.|...|:
Human   754 VTA------GCDPAGVHPPR 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	nop2p	363..637	CDD:188051	87/366 (24%)
		PRK13808	<745..886	CDD:172341	27/129 (21%)
NSUN2	NP_060225.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		9/33 (27%)
		RsmB	<59..431	CDD:439914	93/388 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..481		5/44 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..767		12/53 (23%)